DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSMD9 and CG9588

DIOPT Version :9

Sequence 1:	NP_002804.2	Gene:	PSMD9 / 5715	HGNCID:	9567	Length:	223	Species:	Homo sapiens
Sequence 2:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	219	Identity:	91/219 - (41%)
Similarity:	131/219 - (59%)	Gaps:	23/219 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    15 AGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNI 79
            ||..|...::.|:..|:::||||..|..:|.:...:||:.||||.||:||:|:|:||||.||..|
  Fly     3 AGTTTKERLERLINAKKQLEAQINRNGQILAANDNVGMSGPLVDAEGFPRNDIDVYQVRLARQTI 67

Human    80 ICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSR----KLGQSESQG--------P 132
            ||||||||.:|.|::..|:|.|:        ::|....|.::|    .|....|.|        |
  Fly    68 ICLQNDHKELMNQIQTLLNQYHS--------EIATTDPELVNRASALDLDSDRSPGGANITDLAP 124

Human   133 PRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQ-SLHNIGSVVQHSEGKPLNVTVIRRG 196
            .||...||.:||.|||..|||...|.|:.|||:|:.||: .|..||.:|::.:.:.:.:.| :||
  Fly   125 ARAIVVVNLVSPDSPAERAGLCAGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKV-KRG 188

Human   197 EKH-QLRLVPTRWAGKGLLGCNII 219
            |:. .|.|||..|:|:|||||||:
  Fly   189 EQQLDLILVPKTWSGRGLLGCNIV 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSMD9	NP_002804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..141		10/49 (20%)
PSMD9	NP_002804.2	PDZ_metalloprotease	129..205	CDD:238489	33/85 (39%)
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	26/70 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149216
Domainoid	1	1.000	93	1.000	Domainoid score	I7578
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2106
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4242
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54093
OrthoDB	1	1.010	-	-		D1405146at2759
OrthoFinder	1	1.000	-	-		FOG0004887
OrthoInspector	1	1.000	-	-		oto89143
orthoMCL	1	0.900	-	-		OOG6_102356
Panther	1	1.100	-	-	LDO	PTHR12651
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1021
SonicParanoid	1	1.000	-	-		X4001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800