DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myo1g and Mhc

DIOPT Version :9

Sequence 1:	XP_005170126.1	Gene:	myo1g / 571487	ZFINID:	ZDB-GENE-060503-562	Length:	1010	Species:	Danio rerio
Sequence 2:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster

Alignment Length:	998	Identity:	308/998 - (30%)
Similarity:	480/998 - (48%)	Gaps:	138/998 - (13%)

- Green bases have known domain annotations that are detailed below.

Zfish    26 MENLKLRFEKSRIYTFIGEVVVSVNPYRHLDIYGKDVIEDYRGRELYENPPHLYAVADAAYKAMK 90
            :.||:.|:....|||:.|...|::|||:...:|.....:.|||:...|.|||::|::|.||..|.
  Fly   103 LHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDML 167

Zfish    91 RRAKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVE----SVKNVLLKSNCVLEAFGNA 151
            ....:..::|:|||||||||.:|.::.|.|.:....:..|..    |:::.::::|.||||||||
  Fly   168 TNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNA 232

Zfish   152 KTNRNDNSSRFGKYMDINFNFNGDPTGGHINNYLLEKSRVVQQQEGERNFHSFYQLLRGGSDDLL 216
            ||.||||||||||::.|:|...|...|..|..|||||:||:.||..||::|.|||::.|....:.
  Fly   233 KTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVK 297

Zfish   217 KSLYLQRDPAEYTYTSQGASVTLASNNDSQCHKAVMAALKVIGFTAEEISSIYKTLSTILHLGNL 281
            ....|..:..:|...||| .||:||.:|::.......|..::|||.:|...:|:..:.::|:|.:
  Fly   298 DICLLTDNIYDYHIVSQG-KVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGM 361

Zfish   282 QFTSDG--EHVVLVGEDMLKNISELTSTEPENTRKALLYRTVATGGGEVIEKGHSEQEASYGRDA 344
            :|...|  |.....||:....:|:|...:.....|.||...:.. |.|.:.:|.:.|:.:....|
  Fly   362 KFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKV-GNEFVTQGRNVQQVTNSIGA 425

Zfish   345 FAKALYERLFAWIVGRINGVIEVKDYNPALHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKL 409
            ..|.:::|||.|:|.:.|..::.:      ..:...||||||.|||||:.|.|||.|||:.||||
  Fly   426 LCKGVFDRLFKWLVKKCNETLDTQ------QKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKL 484

Zfish   410 QQLFIELILRQEQEEYQREGITWQHIEYFNNQI-IVDLVEQPHKGIISVLDEACLIAGKVTDTVC 473
            ||.|...:...|||||:||||.|..|::..:.: .:||:|:| .||:|:|:|..:.. |.||...
  Fly   485 QQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKP-MGILSILEEESMFP-KATDQTF 547

Zfish   474 LDSM-NKKLGQHPHYTSRKLCPADKTMEFNRDFRIRHYAGDVTYSVDGFLDKNKDPL----FQDF 533
            .:.: |..||:...:...|   ..|..:....|.|.||||.|:|::.|:|:||||||    ...|
  Fly   548 SEKLTNTHLGKSAPFQKPK---PPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQF 609

Zfish   534 KRLMYNSSDPVLKEMWPD--GKMSITEVTKRP--------LTAATLFKNSIIALVDKLACKEPYY 588
            |:    |.:.:|.|::.|  |:....|..|..        .|.::.:|..:.:|:..|...:|::
  Fly   610 KK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRSTQPHF 670

Zfish   589 VRCIKPNEVKSPLLFDDGRCQHQVAYLGLLENVRVRRAGFAYRQPYARFLQRYKMTCEYTWPNHL 653
            ||||.|||:|.|.:.|.....||:...|:||.:|:.|.||..|..|..|..|||:.|    |..|
  Fly   671 VRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMC----PKLL 731

Zfish   654 --MSTDQEAVEAIVNQHGF----EDDVAYGLNKIFVRTPRTLFTLEQERAALIPILVLFLQKVWR 712
              :..|::|.|.|:.   |    ||....|..|:|.|. ..|..:|:.|...:..::.::|...|
  Fly   732 QGVEKDKKATEIIIK---FIDLPEDQYRLGNTKVFFRA-GVLGQMEEFRDERLGKIMSWMQAWAR 792

Zfish   713 GALARMRCRKIRAIYTIMGYYKCYKVKAHFWEVERRFA---SVRNMADYGKSVEWP-------TP 767
            |.|:|...:|::                     |:|.|   ..||:..|.:...||       ..
  Fly   793 GYLSRKGFKKLQ---------------------EQRVALKVVQRNLRKYLQLRTWPWYKLWQKVK 836

Zfish   768 PAALAQFHRITQHLYRRWWARQLIKNIPPSDMAEVRA--------------KVAAFSALSGERMD 818
            |  |....||...:.|   ..:..|.......|||:.              |.|...:||||:
  Fly   837 P--LLNVSRIEDEIAR---LEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEK-- 894

Zfish   819 WGYSRSW-ERDYLANAKDSPLMSSNFVR-ITKELKNKDQYGQVLFSSAVRMLNWFNNTKDRALLI 881
             |..:.: ||:....|:.:.|  .|.:| |.:.|..::.....||..        ....|:.:..
  Fly   895 -GALQDYQERNAKLTAQKNDL--ENQLRDIQERLTQEEDARNQLFQQ--------KKKADQEISG 948

Zfish   882 TDKHIYRLEPKKHFKVQKRIALDSVVGLSVTSGSDQLVVLHTATQDDFLVHLQR-----GQLNPN 941
            ..|.|..||    ..|||.....:.....:.:.:|::     |.||:.:..|.:     |:.|
  Fly   949 LKKDIEDLE----LNVQKAEQDKATKDHQIRNLNDEI-----AHQDELINKLNKEKKMQGETN-- 1002

Zfish   942 QDRVGELVGAITD---HFTRVKS 961
             .:.||.:.|..|   |..:||:
  Fly  1003 -QKTGEELQAAEDKINHLNKVKA 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo1g	XP_005170126.1	MYSc	8..696	CDD:214580	245/697 (35%)
		MYSc_Myo1	23..684	CDD:276829	242/685 (35%)
		Myosin_TH1	805..1002	CDD:283635	39/167 (23%)
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	245/698 (35%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	242/685 (35%)
		Myosin_tail_1	842..1897	CDD:279860	46/211 (22%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000