Protein Alignment ADCK1 and D2023.6

DIOPT Version :9

• Sequence 1: NP_001353416.1
• Gene: ADCK1 / 57143
• HGNCID: 19038
• Length: 580
• Species: Homo sapiens
• Sequence 2: NP_505980.1
• Gene: D2023.6 / 179618
• WormBaseID: WBGene00008410
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 229/562 - (40%)
• Similarity: 322/562 - (57%)
• Gaps: 64/562 - (11%)

Human     3 RKALKLASWTSMAL----AASGIYFYS-NKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPY 62
            ||.|.....|.:..    |.:|...|: :...|....|.:|.|||.:|...|..||.|||:.:|.
 Worm     4 RKILAFKPLTKVLFVGTGAGAGYTAYTVDSVEDLRQLGLLRFGRAASTVGKIVIDYKTSLRGLPE 68

Human    63 GSEEYLQLRSKVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSM 127
            .|.||.....|.|.|||..|.||.|.|.|.|||||||:..::||:|.|||.||.:|.|||||:|.
 Worm    69 PSSEYDDAIKKCHQRSAEHLLELACVNGGVFIKVGQHISGMEYLIPPEYTQTLSILTSQAPQASK 133

Human   128 QEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHD-GRTVAVKVQHPKVRAQSSKDIL 191
            :::..|:..:|..::.|||..|.:.|:|.|||||||||.|.: |.||||||||.:|...|..|:.
 Worm   134 EDVIYVVESELNAKVGDLFSEFSEKPVGAASLAQVHKAKLKESGETVAVKVQHKRVYKNSRTDVN 198

Human   192 LMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLS 256
            .||.||.....:||||..||||||.|||||.|||||:|.:||::.:|..:|..||::|:|.:||:
 Worm   199 TMEFLVKVADAVFPEFRLMWLVDEIKKNLPNELDFLHEAKNADEAAQRFKHLKFLRIPKIKYDLT 263

Human   257 TERVLLMEFVDGGQVNDRDYMERNKIDVNEVRSRAQGCCAGERGLGQGCPGSACVSRSSEKVSHL 321
            |.|||.|||.:|..|:|.:|:::|.||                      |...|:.
 Worm   264 TTRVLTMEFCEGAHVDDVEYLKKNNID----------------------PHDVCMK--------- 297

Human   322 LSANDFSSSYHVQALSALATIEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVL 386
                                      :||..|||||:.|::|.||||||||:.. .|.||.||||
 Worm   298 --------------------------IGKTISEMIFLQGYLHSDPHPGNVLINS-LGNGKYEIVL 335

Human   387 LDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGIS 451
            ||||||..:::..|..|..||.:::..|::.:::.:.::|.|:||.|||||:|.|||.||..||.
 Worm   336 LDHGLYLNISDHIRKLYSDLWLAILKPDLQEIRKVASQMGVGELYGLFACMVTRRSWKSVTGGIG 400

Human   452 QAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSR 516
            ::.:..:|..|:|..|::.:||||.:|..:||:||||||||||:|.||..||...|:...:.|||
 Worm   401 KSKMNESEKDELRMYASSLIPQISEVLARMPREMLLILKTNDLMRNIEHKLGVFGSSDGHIEMSR 465

Human   517 CCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILR 558
            |.||:..:...:.:.|...:.:|.|...::|.::.:::..||
 Worm   466 CVIRSSHDLAIRRSDSLLGKFKIGFHMYWSLMKLCIYQYYLR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCK1	NP_001353416.1	ADCK1-like	117..426	CDD:270871	123/309 (40%)
D2023.6	NP_505980.1	ADCK1-like	123..375	CDD:270871	123/309 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161454963
Domainoid	1	1.000	218	1.000	Domainoid score	I1685
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6493
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1075
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57752
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto22039
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1843
SonicParanoid	1	1.000	-	-		X3709
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800