Protein Alignment RTN4 and Rtnl1

DIOPT Version :10

• Sequence 1: NP_065393.1
• Gene: RTN4 / 57142
• HGNCID: 14085
• Length: 1192
• Species: Homo sapiens
• Sequence 2: NP_001162875.1
• Gene: Rtnl1 / 33721
• FlyBaseID: FBgn0053113
• Length: 607
• Species: Drosophila melanogaster
• Alignment Length: 788
• Identity: 212/788 - (26%)
• Similarity: 324/788 - (41%)
• Gaps: 228/788 - (28%)

Human   435 EKDSESSNDDTSFPSTPEGIKDR-----SGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDE 494
            :|::.::|:|. |.......:|.     :|.....|..:.|.||....|              ::
  Fly     9 KKEAAATNEDI-FKQAQRAYEDSALGGDTGNVSGGAQDDNAHTEHYFAN--------------EQ 58

Human   495 KKIEEKKAQIVTEKNTSTKTSNPFLVA-AQDSETDYVT-----TDN----LTKVTEEVVANMPEG 549
            ||::...||...::          |.| |:|::.|..|     ||:    |....:||...: .|
  Fly    59 KKLDFGDAQEFVQR----------LAADAKDAKLDLDTKFAQKTDDFEDFLRDAGKEVKQGI-SG 112

Human   550 LTPDLVQEACESELNEVTGTKIAYETKMDLVQTSE-VMQESLYPA-AQLCPSFEESEATPSPVLP 612
            ||.|.        :|...|      ....|...|| |.|..:.|| |...|  :.:.|.|:||.|
  Fly   113 LTTDF--------MNAERG------FSAPLAPFSETVAQAPVIPAQAPAVP--DHAPAVPAPVAP 161

Human   613 DIVMEAPLNSAVPSAGASVIQPSSSPLEA------SSVNYESIKHEPENPPPYEEAMSVSLKKVS 671
            ...:.|||.......|:...|| |:||:|      |:.|:            |::.....|.|.:
  Fly   162 APAVPAPLPVEEDLLGSFTDQP-SAPLQAFQPTAPSTANF------------YDDEEDDFLGKPT 213

Human   672 GIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVE 736
                              |.||               |.|....:..::.:..|.|...::
  Fly   214 ------------------TAAP---------------AAPVAPLTKANQDSDTESPSVSYT---- 241

Human   737 DSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLE 801
             .||..:|        |.|..:.||....:..|.|..       :::.:.:.:..|.....|.|:
  Fly   242 -PSPAKKP--------IVDALKDQDNEKFISSEDLAS-------DFKEEPRSAPTPAPAPAPILD 290

Human   802 SFKLSLDNTKDTLLPDEVST-----LSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSD 861
            :        ...:.|..|:.     ::|.:.:|:.:...:..:...||          |...|.
  Fly   291 A--------APAVAPAPVAVPVSVPVAKPQPVPVAVPVTTALITDLDD----------EEVVFK- 336

Human   862 SSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSL--PCTELPHDLSLKNI 924
                      ||:                       .|...||..|..:  |..|.|
  Fly   337 ----------PTV-----------------------QEAPKAPTIAAPVVEPKPEPP-------- 360

Human   925 QPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKED 989
            :||||             .|..||:.:.| |.:...|.:|.|       |:|...|...|
  Fly   361 KPKVE-------------PAKPKVVPVAP-VESTQPQPKIAS-------VEEIFCKYGLD----- 399

Human   990 RSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISF 1054
                |.|..|.....|..|:||||:||:|:||||.|..|.:::.||::||.||::|..|..|::|
  Fly   400 ----AWFKPERLHPQVESLIYWRDVKKSGIVFGAGLITLAAISSFSVISVFAYLSLLTLFGTVAF 460

Human  1055 RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSL 1119
            ||||.|.||:||::|||||:.|||.::.:|.|.||..:..|:.|:|..|.||||||||:|::||:
  Fly   461 RIYKSVTQAVQKTNEGHPFKDYLELDLTLSHEKVQNIAGVAVAHINGFISELRRLFLVEDIIDSI 525

Human  1120 KFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI 1184
            ||.|::||||||||.|||:||:|||.:|||::|.:||.::..||.:|.|....:.:...||:..|
  Fly   526 KFGVILWVFTYVGAWFNGMTLVILAFVSLFTLPKVYENNKQSIDTHLDLVRSKLTEITDKIRVAI 590

Human  1185 PGLKRKAE 1192
            |...:|.|
  Fly   591 PIGNKKPE 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RTN4	NP_065393.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..204
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	427..458		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	722..762		8/39 (21%)
		Reticulon	1005..1169	CDD:460562	89/163 (55%)
Rtnl1	NP_001162875.1	Reticulon	411..575	CDD:460562	89/163 (55%)