DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAZ4 and bol

DIOPT Version :9

Sequence 1:	NP_001375413.1	Gene:	DAZ4 / 57135	HGNCID:	15966	Length:	723	Species:	Homo sapiens
Sequence 2:	NP_001261614.1	Gene:	bol / 39049	FlyBaseID:	FBgn0011206	Length:	233	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	76/282 - (26%)
Similarity:	103/282 - (36%)	Gaps:	94/282 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   182 ASTQSSSAAASQGWVLP-----EGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRT 241
            |:....||....|...|     .|.::||.:|||||.....|.::...|..||:||..|||.:|.
  Fly     5 AAAPPPSATPGGGLETPLAAPKYGTLIPNRIFVGGISGDTTEADLTRVFSAYGTVKSTKIIVDRA 69

Human   242 GVSKGYGFVSFVNDVDVQKIV--GSQIHFHGKKLKLGPAIRKQKLCARHVQPRPL---------- 294
            |||||||||:|..:.:.|::.  |..:....:||.:.|||:|        ||.||
  Fly    70 GVSKGYGFVTFETEQEAQRLQADGECVVLRDRKLNIAPAIKK--------QPNPLQSIVATNGAV 126

Human   295 --VVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEY 357
              ...||.|                   |:..|:.|.  |.:.||........|...:
  Fly   127 YYTTTPPAP-------------------ISNIPMDQF--AAAVYPPVTDFTAAGVPAI------- 163

Human   358 PTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQ--------AFPAYPNSPFQ 414
              ||.||.|           ||||..|...|..|...:.   .|||        :..:.|:||..
  Fly   164 --YPPSAMQ-----------YQPFYQYYSVPMNVPTIWP---QNYQENHSPLLHSPTSNPHSPHS 212

Human   415 VATGYQFPVYNYQPFPAYPSSP 436
                           .::|.||
  Fly   213 ---------------QSHPQSP 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAZ4	NP_001375413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		RRM_DAZL	35..116	CDD:410073
		PABP-1234	42..412	CDD:130689	71/256 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..192		3/9 (33%)
		RRM_DAZL	200..281	CDD:410073	35/82 (43%)
		Daz	407..427	CDD:408642	3/19 (16%)
		Daz	431..451	CDD:408642	3/6 (50%)
		Daz	455..475	CDD:408642
		Daz	479..499	CDD:408642
		Daz	503..523	CDD:408642
		Daz	527..547	CDD:408642
		Daz	551..571	CDD:408642
		Daz	575..595	CDD:408642
		Daz	599..619	CDD:408642
		Daz	623..643	CDD:408642
		Daz	647..667	CDD:408642
		Daz	671..691	CDD:408642
bol	NP_001261614.1	RRM_DAZL_BOULE	31..111	CDD:240858	34/79 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1610446at2759
OrthoFinder	1	1.000	-	-		FOG0002544
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950