DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAZ4 and SPBC23E6.01c

DIOPT Version :9

Sequence 1:	NP_001375413.1	Gene:	DAZ4 / 57135	HGNCID:	15966	Length:	723	Species:	Homo sapiens
Sequence 2:	NP_596601.2	Gene:	SPBC23E6.01c / 2540551	PomBaseID:	SPBC23E6.01c	Length:	473	Species:	Schizosaccharomyces pombe

Alignment Length:	408	Identity:	97/408 - (23%)
Similarity:	152/408 - (37%)	Gaps:	129/408 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    17 ASTQSSSAAASQGWVLPEGKIVPNT--------------------------VFVGGIDARMDETE 55
            ||...:|:|.|.     ..|.:|.|                          :|||.:...::|.:
pombe   142 ASPHEASSAMSM-----NNKPIPGTNHLFKLNWASGGGLREKSISKASEYSIFVGDLSPNVNEFD 201

Human    56 IGSCF-GRYGSVKEVKIITN-RTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQK 118
            :.|.| .||.|.|..||:|: :|.||:|||||.|.::.|.:..:               |..:.:
pombe   202 VYSLFASRYNSCKSAKIMTDPQTNVSRGYGFVRFTDENDQKSAL---------------AEMQGQ 251

Human   119 LCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREAS 183
            :|.    .||:.|....|....:|:...|......|     ||..:  |||.|      :.:.|.
pombe   252 ICG----DRPIRVGLATPKSKAHVFSPVNVVPVSMP-----PVGFY--SAAQP------VPQFAD 299

Human   184 TQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYG 248
            |.:|                  ||||||:...:.|.|:...|..:|.:..|||     ...||.|
pombe   300 TANS------------------TVFVGGLSKFVSEEELKYLFQNFGEIVYVKI-----PPGKGCG 341

Human   249 FVSFVN----DVDVQKIVGSQIHFHGKKLKLG--------PAIRKQKLCARHVQPRPLV---VNP 298
            ||.|||    ::.:.::.|..:.....:|..|        ||:..|...::...|...:   ::.
pombe   342 FVQFVNRQSAEIAINQLQGYPLGNSRIRLSWGRNQNPIAAPALNYQSQVSQTTIPATSLFPAMSL 406

Human   299 PPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSP-GQVIT-GCQLLVYNYQEYPTYP 361
            ||..||     :|      .|.:.|:|:....:.      :| |..|: |...||.:....|...
pombe   407 PPQAQF-----SP------YPAVAPSPLALQTRG------APIGMEISIGSPALVPDQMHIPENG 454

Human   362 DSAFQVTTGYQLPVYNYQ 379
            :|.       .:||.|.|
pombe   455 NSD-------TMPVPNTQ 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAZ4	NP_001375413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		4/9 (44%)
		RRM_DAZL	35..116	CDD:410073	27/108 (25%)
		PABP-1234	42..412	CDD:130689	89/357 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..192		7/28 (25%)
		RRM_DAZL	200..281	CDD:410073	26/92 (28%)
		Daz	407..427	CDD:408642
		Daz	431..451	CDD:408642
		Daz	455..475	CDD:408642
		Daz	479..499	CDD:408642
		Daz	503..523	CDD:408642
		Daz	527..547	CDD:408642
		Daz	551..571	CDD:408642
		Daz	575..595	CDD:408642
		Daz	599..619	CDD:408642
		Daz	623..643	CDD:408642
		Daz	647..667	CDD:408642
		Daz	671..691	CDD:408642
SPBC23E6.01c	NP_596601.2	RRM	70..376	CDD:223796	73/293 (25%)
		RRM1_NGR1_NAM8_like	94..173	CDD:241055	8/35 (23%)
		RRM2_NGR1_NAM8_like	185..264	CDD:241057	28/97 (29%)
		RRM3_NGR1_NAM8_like	302..373	CDD:240792	24/93 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910