Protein Alignment NUP107 and NUP84

DIOPT Version :10

• Sequence 1: NP_065134.1
• Gene: NUP107 / 57122
• HGNCID: 29914
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_010167.1
• Gene: NUP84 / 851441
• SGDID: S000002274
• Length: 726
• Species: Saccharomyces cerevisiae
• Alignment Length: 808
• Identity: 168/808 - (20%)
• Similarity: 328/808 - (40%)
• Gaps: 150/808 - (18%)

Human   155 FSDFLQSFL-----KHSSSTVFDLVEEYENIC----------GSQVNILSKIVSRATPGLQKFSK 204
            |||.|:.|.     :.:....|:::.|:.:..          |.:.|::|
Yeast    15 FSDTLKEFKIEQNNEQNPIDPFNIIREFRSAAGQLALDLANSGDESNVIS--------------- 64

Human   205 TASMLWLLQQEMVTWRL--LASLYRDRIQSALEEESVFAVTAVNASEKTVVEALFQRDSLVRQSQ 267
              |..|.|:...  |.|  |..::|: ....|:|..:....:....||    .|.|.:..:.|..
Yeast    65 --SKDWELEARF--WHLVELLLVFRN-ADLDLDEMELHPYNSRGLFEK----KLMQDNKQLYQIW 120

Human   268 LVVDWLESIAKDEIGEFSDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQK 332
            :|:.||:.  ...:.|...|:    .:..|.|:        :||  |.::    ..|.|.|:|:.
Yeast   121 IVMVWLKE--NTYVMERPKNV----PTSKWLNS--------ITS--GGLK----SCDLDFPLREN 165

Human   333 M-PLDDLDREDEVRLLKYLFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNG--GTE 394
            . .||..|:|::....||::.||.||..:||....|..........|.|.:.|.:|.::.  ..|
Yeast   166 TNVLDVKDKEEDHIFFKYIYELILAGAIDEALEEAKLSDNISICMILCGIQEYLNPVIDTQIANE 230

Human   395 LEPVEGNPYRRIWKISCWRMAEDELFNRYERAIYAALSGNL--KQLLPVCDTWEDTVWAYFRVMV 457
            ....:|.....:|:.:.:.:::....:.||||||:.|||.:  :::|...| ||..:..:...::
Yeast   231 FNTQQGIKKHSLWRRTVYSLSQQAGLDPYERAIYSYLSGAIPNQEVLQYSD-WESDLHIHLNQIL 294

Human   458 DSLVEQEI--QTSVATLDETEELPREYLGANWTLEKVFEELQATDKKRVLEENQEHYHIVQKFLI 520
            .:.:|..:  ...|.|.:....||...|    |:::|...:.:    |...|::....::...:|
Yeast   295 QTEIENYLLENNQVGTDELILPLPSHAL----TVQEVLNRVAS----RHPSESEHPIRVLMASVI 351

Human   521 LGDIDGLMDEFSKWL------SKSRNNL--PGHLLRFMTHLILFFRTLGLQTKEEV-SIEVLKTY 576
            |..:..::....:.|      :::.|::  ..:|||.:|||.:....:...:.||| ..:::.||
Yeast   352 LDSLPSVIHSSVEMLLDVVKGTEASNDIIDKPYLLRIVTHLAICLDIINPGSVEEVDKSKLITTY 416

Human   577 IQLLIREKHTNLIAFYTCHLPQDLAVAQYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVE 641
            |.||..:.....|..|...|.:...:...:..|.|:.:.:.|...:|......|..:.|.:...:
Yeast   417 ISLLKLQGLYENIPIYATFLNESDCLEACSFILSSLEDPQVRKKQIETINFLRLPASNILRRTTQ 481

Human   642 NIRKKDNGEFS-HHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRAEALKQGNAIMRKFLASKKH 705
            .:..:...|:| .::::.:.|....  |...|..::||: :.....:|:....|:.|:||.:.:.
Yeast   482 RVFDETEQEYSPSNEISISFDVNNI--DMHLIYGVEWLI-EGKLYVDAVHSIIALSRRFLLNGRV 543

Human   706 EAAKEVFVKIPQDSIAEIYNQCEEQGMESPLPAEDDNAIR--------EHLC--IRAYLEAHETF 760
            :|.::.   :.:::|.||....|.:.:...: ::|:|..:        |||.  ||.|
Yeast   544 KALEQF---MERNNIGEICKNYELEKIADNI-SKDENEDQFLEEITQYEHLIKGIREY------- 597

Human   761 NEWFKHMNSVPQKPALIPQPTFTEKVAHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVD 825
            .||.|.::.:..:..:   ||..||:....|:     .|.:.|..|..||:.         .|.|
Yeast   598 EEWQKSVSLLSSESNI---PTLIEKLQGFSKD-----TFELIKTFLVDLTSS---------NFAD 645

Human   826 GGWMVDVREDAKEDHERTHQMVLLRKLCLPMLCFLLHTILHSTGQ-------YQECLQLADMVSS 883
            ..           |:|..::   :|.|..|.|...||..|....:       ..|.|....:|::
Yeast   646 SA-----------DYEILYE---IRALYTPFLLMELHKKLVEAAKLLKIPKFISEALAFTSLVAN 696

Human   884 ERHKLYLVF-SKEELRKLLQKLRESSLM 910
            |..|:||:| |..:|::.|..:..::.:
Yeast   697 ENDKIYLLFQSSGKLKEYLDLVARTATL 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP107	NP_065134.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..66
		Nup84_Nup100	209..908	CDD:461184	157/735 (21%)
NUP84	NP_010167.1	Nup84_Nup100	66..722	CDD:461184	157/736 (21%)