Protein Alignment NUP107 and npp-5

DIOPT Version :10

• Sequence 1: NP_065134.1
• Gene: NUP107 / 57122
• HGNCID: 29914
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_496481.1
• Gene: npp-5 / 174779
• WormBaseID: WBGene00003791
• Length: 813
• Species: Caenorhabditis elegans
• Alignment Length: 871
• Identity: 176/871 - (20%)
• Similarity: 312/871 - (35%)
• Gaps: 253/871 - (29%)

Human   103 TNLDDSNW----AAAF------SSQRSGLFTNTEPHSITEDVTISAVMLREDDPGEAASMSMFSD 157
            |||.:..:    |.||      ..|.|.|.. |..|.|..:|.:....|.......|:|....::
 Worm    38 TNLSEKLYHELCALAFGEFDIPQGQISPLMW-TRLHEIYSEVEMQTRKLPAGSNYSASSQKYANE 101

Human   158 FLQSFLKHSSSTVFDLVEEYENICGSQVNILSKIVSRATPGLQKFSKT-ASMLWLLQQEMVTWRL 221
            .:|  :....|....|..||:...  :|::|||:|....    :|.:. |.:||
 Worm   102 AVQ--IASVLSIYTALAHEYDETV--EVSLLSKLVVEDV----EFRRIYALLLW----------- 147

Human   222 LASLYRDRIQSALEEESVFAVTAVNASEKTVVEALFQR--DSLVRQSQLVVDWLESIAKDEIGEF 284
                                      |||.:.|..:::  ...||:       ||.|....|
 Worm   148 --------------------------SEKAISEQQYEKGLGDKVRK-------LEGIKSSRI--- 176

Human   285 SDNIEFYAKSVYWENTLHTLKQRQLTSYVGSVRPLVTELDPDAPIRQKMPLDDLDREDEVRLLKY 349
                          |::..||:   .::..:..|....||||||..::      |:..|...:..
 Worm   177 --------------NSMMALKR---PTFGAANAPKDASLDPDAPGTKE------DQALEQMAMNV 218

Human   350 LFTLIRAGMTEEAQRLCKRCGQAWRAATLEGWKLYHDPNVNGGTELE-PVEGN-----PYRRIWK 408
            .|.|||:|.|.:|..|....|.....|.|:...:..:|       |: |:|.:     .|:|..:
 Worm   219 FFQLIRSGETSKAANLAIDLGMGAIGAQLQLHSMLRNP-------LDIPLEASKQNFGEYKRSRR 276

Human   409 ISCWRM----------AEDELFNRYERAIYAALSGNLKQLLPVCDTWEDTVWAYFRVMVDSLVEQ 463
            ...::|          :||:.:    ..:.:|:.||::.:|....:..:.||||    .:|.|..
 Worm   277 AKYYQMTQKLIEQSQGSEDDAY----WMLISAIRGNIQPMLKAGKSVIEKVWAY----ANSAVLA 333

Human   464 EIQTSVATLDETEELPREYLGANWTLEKVFEELQA-TDKKRVLEENQEHYHIVQKFLILGDIDGL 527
            .|..:...:  |:|..........|.:.:.:||:: .|:.:            :.:::|..||.:
 Worm   334 RILAAEGAM--TQETISTLFNVPLTSKSILDELRSEADRTK------------EVYILLRVIDDM 384

Human   528 MDEFSKWLSKSRNNLPGHL-------------LRFMTHLILFFRTLGLQTKEEVSIEVLKTYIQL 579
            :::..:.|.|..|...|..             |....||:......|.:..::.:..::..:..|
 Worm   385 LNDDIEDLYKFANETVGEFVPNDKNCQVNMLALDIFFHLVAVSYASGFEPNDDGNAVIILGFDDL 449

Human   580 LIR---EKHTNLIAFYTCHLPQDLAVAQYALFLESVTEFEQRHHCLELAKEADLDVATITKTVVE 641
            ..|   ..|..:.|||:..||:|:.:.:....:::|...|:|....|..|::|:|......|::|
 Worm   450 RARSGTSSHKKMAAFYSRFLPEDMKLPEIVETMKAVDSDEEREILAESLKQSDIDFGRCACTLIE 514

Human   642 NIRKKDNGEFSHHDLAPALDTGTTEEDRLKIDVIDWLVFDPAQRA-EALKQGNAIMRKFLASKKH 705
            .|||.|..:           ..|.||   :||...||:....:.| .||::.|.::||.:.|...
 Worm   515 QIRKDDKTK-----------VVTLEE---QIDHWHWLLIGGEETALAALEECNRLVRKVMLSTPI 565

Human   706 EAA-------KEVFVKIPQDSIAEIYNQCE-----------EQGMESPLPAEDDNAIREHLCIRA 752
            :.:       |.:..::|:.....:.|:..           ||...|.|..   |.| ||..:..
 Worm   566 DESVIRQIIRKALHFEVPKLLSQAVENEATVLSLITDGTLFEQKPGSQLAI---NKI-EHAALEF 626

Human   753 Y-LEAHETFNEW-----------FKHMNSVPQKPALI-----------------------PQPTF 782
            | |.:....|.:           ||:......:.::|                       .:.|.
 Worm   627 YGLCSFVDVNNFMITIALKLGLMFKYTPITDDELSMIGGVKRLDNTTAADWEASLRVRARAEQTL 691

Human   783 TEKV----AHEHKEKKYEMDFGIWKGHLDALTADVKEKMYNVLLFVDGGWMVDVRED------AK 837
            .|:|    |.||..:     .|:.:.|||.:...::..:.|          :.||.:      |.
 Worm   692 REEVLKKRAAEHNTR-----VGMVQQHLDTVLPMLRGLVNN----------IGVRPEYFLSPRAN 741

Human   838 EDHERTHQMVL--LRKLCLPMLCFLL 861
            .|..|.|:..:  :|.|.||....||
 Worm   742 GDPMRVHRKEIQEIRNLFLPQFFILL 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUP107	NP_065134.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..66
		Nup84_Nup100	209..908	CDD:461184	148/754 (20%)
npp-5	NP_496481.1	Nup84_Nup100	113..>539	CDD:461184	111/544 (20%)