Protein Alignment TRPC7 and trpc3

DIOPT Version :10

• Sequence 1: NP_065122.1
• Gene: TRPC7 / 57113
• HGNCID: 20754
• Length: 862
• Species: Homo sapiens
• Sequence 2: XP_002941939.2
• Gene: trpc3 / 100490905
• XenbaseID: XB-GENE-1014039
• Length: 917
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 672/846 - (79%)
• Similarity: 760/846 - (89%)
• Gaps: 10/846 - (1%)

Human    12 RRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDY 76
            ||.|.:||||||||:||||:|||.:|.:||.|||||||:||||||||||||||||||||.|||||
 Frog    78 RRVTMIREKGRRQAVRGPAFMFNNRGPNLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDY 142

Human    77 MGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSP 141
            |||||||||||||||||:||||||:||||:||||||||||||||||||||||||||..:||||||
 Frog   143 MGQNALQLAVGNEHLEVSELLLKKDNLARIGDALLLAISKGYVRIVEAILNHPAFAASKRLTLSP 207

Human   142 LEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEK 206
            .||||:|||||:|||||||||.||||||||||||:||:||:||:|||:|||||||||||::||||
 Frog   208 CEQELQDDDFYSYDEDGTRFSPDITPIILAAHCQKYEVVHMLLVKGAKIERPHDYFCKCSDCTEK 272

Human   207 QRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCK 271
            |:.|||||||||:||||||||.|||||||||||.||||||||||:|||||.||||||||||||||
 Frog   273 QKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVHTALELSNELAKLANIEKEFKNDYRKLSMQCK 337

Human   272 DFVVGVLDLCRDTEEVEAILNGDVNFQ-VWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTM 335
            ||||||||||||:|||||||||||:.: :.|..|||||||:|||||||||||||||||||||||:
 Frog   338 DFVVGVLDLCRDSEEVEAILNGDVDAEPIESQRHRPSLSRVKLAIKYEVKKFVAHPNCQQQLLTI 402

Human   336 WYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLG 400
            |||||||||:|.||:|.|.|..|::||||||:.|||||||:|||.||||||||||||.||.|||.
 Frog   403 WYENLSGLREQPIAIKCLVVLVVALGLPFLAVGYWIAPCSRLGRILRSPFMKFVAHAASFIIFLC 467

Human   401 LLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPRE 465
            |||.||||||||:|||||.|..:|||||||||||:|:|||||||.|||||:||||||:|.|||||
 Frog   468 LLVFNASDRFEGIKTLPNITVIEYPKQIFRVKTTRFTWTEMLIMVWVLGMMWSECKELWLEGPRE 532

Human   466 YVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDK 530
            |:|.|||:|||||||||:|:||||.:||::||:||.|||:::|::.|..|:||||:.||||||||
 Frog   533 YILQLWNVLDFGMLSIFIAAFTARLLAFMQATKAQQYVDKYIQENDLSLVTLPPEIEYFTYARDK 597

Human   531 WWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMI 595
            |.||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||:||||
 Frog   598 WLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMI 662

Human   596 GMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTM 660
            |||.|||||.|||.|.||||||||||||||||||||||.||||||||||||||||||||:|||||
 Frog   663 GMFILYSYYLGAKVNSAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTM 727

Human   661 VVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRI 725
            |||||||||||||:||||||:|:||||||||:||||||||:|:|||.||::|||||||.|.|::|
 Frog   728 VVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSIVPSPKSFVYFILKI 792

Human   726 KMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRY-QAGMRNSENLTANNTLSKPTRYQKIMKRLIK 789
                |.|.|.:.:..:.|.|:||.:||.:...: |:..|..|:.:.|:.:::|||||:|||||||
 Frog   793 ----INLFKCRRRRLQKDTEIGMGDSKSRLNLFSQSTTRVFESRSFNSIINQPTRYQQIMKRLIK 853

Human   790 RYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHL 854
            ||||:||||:||||||||||||||||||||||||||:|||||.||:.||.:||||    ||...|
 Frog   854 RYVLRAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELSSLIHKLSEK----LNPGML 914

Human   855 R 855
            |
 Frog   915 R 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRPC7	NP_065122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		5/8 (63%)
		trp	27..822	CDD:273311	639/796 (80%)
		ANK 1	42..71		26/28 (93%)
		ANK repeat	77..108	CDD:293786	27/30 (90%)
		ANK 2	77..106		26/28 (93%)
		ANK 3	108..134		25/25 (100%)
		ANK repeat	109..155	CDD:293786	39/45 (87%)
		ANK repeat	157..192	CDD:293786	28/34 (82%)
		ANK 4	163..192		22/28 (79%)
trpc3	XP_002941939.2	trp	93..886	CDD:273311	639/796 (80%)
		ANK repeat	143..174	CDD:293786	27/30 (90%)