Protein Alignment PSMD5 and CG12096

DIOPT Version :10

• Sequence 1: NP_005038.1
• Gene: PSMD5 / 5711
• HGNCID: 9563
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_572862.2
• Gene: CG12096 / 32269
• FlyBaseID: FBgn0030457
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 133/534 - (24%)
• Similarity: 241/534 - (45%)
• Gaps: 96/534 - (17%)

Human    21 ELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLL------QAMEPV- 78
            :|:||.|..|              ||..| :.:|....::..|...|:||||      ....|.
  Fly    11 KLKALESKPQ--------------RLDAL-TAMNSAIAKEAALPRQIIERLLTTDQLYDCANPAA 60

Human    79 --HVARNLRVD-------------------------LQRGLIHPDDSVKILTLSQIGRIVENSDA 116
              ||.::..||                         |:|||.|.:.:::...|:.:.:.:.....
  Fly    61 DSHVPKDQAVDVTLELLCHCLDQLAMDTADEQLSSLLRRGLTHSNPALRAQVLASLFKKLLRQLT 125

Human   117 VTEILN--NAELLKQIVYCIGGENLSVAKAAIKSLSRI---SLTQAGLEALFESNLLDDLKSVMK 176
            |.::|.  |.||:..|:..:...:......||..||.:   .::.|.::|        .|..::|
  Fly   126 VGQVLTLPNNELIFLILDELKQPDTQSTSLAINILSIVLPQRISNADVQA--------KLVQLLK 182

Human   177 TNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGR 241
            .|:|||.|.|||.:.::..|...|:..|.  ::...|.||..:|||::|:.:|::..||..:||.
  Fly   183 QNEIVRCRAYELAVVLAKKSATLLSDVTF--ILDAALSELDNDDVLLQASVMELLVPLAEQNHGL 245

Human   242 QYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKVFEMIES 306
            .|:.:..|:|.||..:...:..|..:..:|..:||||.::|. .|.:|...||..:..:|..::|
  Fly   246 SYMERRRVLDIISYRVQRVEEHPLDALLVPSIMKFFGKISVY-QPLKIIGGYPHMLACLFMQLQS 309

Human   307 QDPTMIGVAVDTVGILGSNVEGKQVLQK--TGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLL 369
            :|.:::..|:||:..|.:..:||.:|..  :|. .|:...:.|..:|.....:|.|.|::: .::
  Fly   310 EDESILPTAMDTLANLATTPQGKILLNMHFSGA-MEKSFKKYGSHTKKLSAHIKKRLLNSL-DVI 372

Human   370 Y---LPPEQQTDDLLRMTESWFSSLSRDPLELFRG---------ISSQPFPELHCAALKVFTAIA 422
            |   .||   ..:::.:.::|:        |.|.|         :.:.|||:|..|||.....|.
  Fly   373 YDFKTPP---ATEIINIGKNWY--------ECFAGGAHANIIMDLINTPFPDLQMAALSFLKTIC 426

Human   423 NQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSE 487
            ...|....:.|:.|.||:::.|..:..:..|..|:::::.|:.|   || |.....:|...|::|
  Fly   427 KYNWGIVALKNTGGAVEFLLSRQKDLHRDIKYMKWQIMEILSAS---AE-FSPTETIRFTAYVNE 487

Human   488 GPYYVKPVSTTAVE 501
            |||:|:.....|.|
  Fly   488 GPYHVQADLDVATE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMD5	NP_005038.1	Proteasom_PSMB	1..504	CDD:463124	133/534 (25%)
		HEAT repeat	88..112	CDD:293787	6/23 (26%)
		HEAT repeat	125..155	CDD:293787	7/32 (22%)
		HEAT repeat	166..191	CDD:293787	10/24 (42%)
		HEAT repeat	202..229	CDD:293787	8/26 (31%)
CG12096	NP_572862.2	Proteasom_PSMB	4..506	CDD:463124	133/534 (25%)