Protein Alignment PNPLA2 and Pnpla2

DIOPT Version :10

• Sequence 1: NP_065109.1
• Gene: PNPLA2 / 57104
• HGNCID: 30802
• Length: 504
• Species: Homo sapiens
• Sequence 2: NP_001101979.2
• Gene: Pnpla2 / 361676
• RGDID: 1309044
• Length: 478
• Species: Rattus norvegicus
• Alignment Length: 478
• Identity: 418/478 - (87%)
• Similarity: 437/478 - (91%)
• Gaps: 8/478 - (1%)

Human     1 MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGVCLGEA 65
            |||||..||||||||||||||::||||||||||||||||||||||||||||||||||||.|||||
  Rat     1 MFPRETKWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGEA 65

Human    66 GAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTRVSDGENVIIS 130
            ||..|||||||||||||||||||||||.||..|||.||||.|..|||||||||||||||||||||
  Rat    66 GANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTLPADCHTRASGRLGISLTRVSDGENVIIS 130

Human   131 HFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICP 195
            ||:||||||||||||.|||||||||||:|||||||||||||||||||||||||||||||||||||
  Rat   131 HFSSKDELIQANVCSTFIPVYCGLIPPTLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICP 195

Human   196 QDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLQRNGLLNRPNP 260
            |||||||||||:||||||||||||||||||||||||:|||||||||||||||||:||||||:|||
  Rat   196 QDSSTNIHELRITNTSIQFNLRNLYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNP 260

Human   261 LLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNM 325
            ||||||..|    .::.|.|:|..|:  :..|||.||||||||||||||||||||.||:||||||
  Rat   261 LLALPPVVP----QEEDAEEAAVTEE--RTGGEDRILEHLPARLNEALLEACVEPKDLMTTLSNM 319

Human   326 LPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGRHLP 390
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||.|||
  Rat   320 LPVRLATAMMVPYTLPLESAVSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGDHLP 384

Human   391 SRLPEQVELRRVQSLPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFP 455
            |||.|||||||.|||||||||||.|.||||.|:||||||||||||||||||||||||||||||||
  Rat   385 SRLSEQVELRRAQSLPSVPLSCATYSEALPNWVRNNLSLGDALAKWEECQRQLLLGLFCTNVAFP 449

Human   456 PEALRMRAPADPAPAPADPASPQ 478
            |:||||||||  :|...|||:||
  Rat   450 PDALRMRAPA--SPTATDPATPQ 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA2	NP_065109.1	Pat_PNPLA2	4..252	CDD:132859	227/247 (92%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	14..19		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	45..49		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	166..168		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	463..492		9/16 (56%)
Pnpla2	NP_001101979.2	Pat_PNPLA2	4..252	CDD:132859	227/247 (92%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	14..19		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	45..49		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	166..168		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..478		10/17 (59%)