DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C12orf4 and zgc:154077

DIOPT Version :9

Sequence 1:	NP_001291740.1	Gene:	C12orf4 / 57102	HGNCID:	1184	Length:	552	Species:	Homo sapiens
Sequence 2:	NP_001071257.1	Gene:	zgc:154077 / 777745	ZFINID:	ZDB-GENE-061110-34	Length:	551	Species:	Danio rerio

Alignment Length:	551	Identity:	428/551 - (77%)
Similarity:	492/551 - (89%)	Gaps:	1/551 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKKNRERFCNREREFVYKFKVGSQCLELRVPLKFPVQENASHLHGRLMLLHSLPCFIEKDLKEAL 65
            |:||:.:....|:|||::||.|.....|:||||||::||.|.||||:||||.:|||:|.|||..|
Zfish     1 MRKNKGKTNTIEKEFVFEFKAGKHHCVLKVPLKFPLKENVSDLHGRIMLLHRIPCFVETDLKNRL 65

Human    66 TQFIEEESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYH 130
            ..|||.|:|:||||||||:|..:.|||||:::|.:.|||||:|||||||||||.|||||||.|||
Zfish    66 GSFIESETLADYDRDAEAALQKLTSGEVDINKLTNLWAKAYSETTLEHARPEEASWDEDFASVYH 130

Human   131 DLIHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAA 195
            :||||||||||||||||||||:||||.|||:|||||:|||.:||.||||||||:|.|||||::||
Zfish   131 ELIHSPASETLLNLEHNYFVSVSELISERDMELKKLQERQAVEMNKVMQELGKTLCDQDVNTVAA 195

Human   196 QHFESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESVEAI 260
            ||||:||.||:||::||||.|.||||||||||:|||:||:|||||:::|||||||.|..|:.||.
Zfish   196 QHFEAQQVLESKWASELKQVTGIQKQEYQEWVMKLHRDLQNPNNSTINEEIKVQPGQLGEAGEAA 260

Human   261 GRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYSTSL 325
            .|::||||:|||||||||||||||||||||:|:|:||||||:|:..|||||.|||||||||||||
Zfish   261 DRLFEEQRQLEESFTIHLGAQLKTMHNLRLVRSDVLDFCKHRRHSSSGVKLRRLQTALSLYSTSL 325

Human   326 CGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLDSG 390
            ||||||||||:|||||||||||||.||||||||||::||||:|||||||||.||.||.:|..:.
Zfish   326 CGLVLLVDNRVNSYSGIKRDFATVSQECTDFHFPRVDEQLEIVQQVVLYARAQRNSKQREQPEM- 389

Human   391 NQNGGNDDKTKNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKSGNITARDPAIMGLRN 455
            .:||||:||.|..:||..|:|.|||||||||||||:|:.|||||||:|:||||||||||||||||
Zfish   390 PRNGGNEDKNKILDRNSSNILQGEFYITRHSNLSEVHIVFHLCVDDNVRSGNITARDPAIMGLRN 454

Human   456 ILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLV 520
            |||||||||||||:|||||||||||||||||||:|||||||||||||||||||||||||||||||
Zfish   455 ILKVCCTHDITTITIPLLLVHDMSEEMTIPWCLKRAELVFKCVKGFMMEMASWDGGISRTVQFLV 519

Human   521 PQSISEEMFYQLSNMLPQIFRVSSTLTLTSK 551
            |||||||||||||||||||||||||||||||
Zfish   520 PQSISEEMFYQLSNMLPQIFRVSSTLTLTSK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C12orf4	NP_001291740.1	DUF2362	41..546	CDD:313393	402/504 (80%)
C12orf4	NP_001291740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..403		8/19 (42%)
zgc:154077	NP_001071257.1	DUF2362	41..545	CDD:287163	402/504 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343216
Domainoid	1	1.000	831	1.000	Domainoid score	I728
eggNOG	1	0.900	-	-		E1_KOG4506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	881	1.000	Inparanoid score	I2951
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52561
OrthoDB	1	1.010	-	-		D156291at7742
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto51735
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300