DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C12orf4 and c12orf4

DIOPT Version :9

Sequence 1:	NP_001291740.1	Gene:	C12orf4 / 57102	HGNCID:	1184	Length:	552	Species:	Homo sapiens
Sequence 2:	XP_012814318.1	Gene:	c12orf4 / 493240	XenbaseID:	XB-GENE-994282	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	430/552 - (77%)
Similarity:	478/552 - (86%)	Gaps:	3/552 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKKNRERFCNREREFVYKFKVGSQCLELRVPLKFPVQENASHLHGRLMLLHSLPCFIEKDLKEAL 65
            ||..:.:....:|:|||.|:.|.|...|.|||:||||||..||||||||||:||||:|||||::|
Frog    64 MKPGKAKISYTQRDFVYSFQAGPQKFALTVPLQFPVQENLDHLHGRLMLLHNLPCFVEKDLKQSL 128

Human    66 TQFIEEESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYH 130
            .:|:|:|::.||||:||.:|.|:....|...:|::||.|||.||||||||||||:|||||||:||
Frog   129 CRFVEKETVKDYDREAELALEAMSLSAVATEKLSNTWMKAYTETTLEHARPEEPNWDEDFADIYH 193

Human   131 DLIHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAA 195
            |||||||||||||||||||:|||||:.||||||||||||||.||.|||||||||||||||||:||
Frog   194 DLIHSPASETLLNLEHNYFLSISELLSERDVELKKLRERQGTEMNKVMQELGKSLTDQDVNSVAA 258

Human   196 QHFESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESVEAI 260
            |||||||.||||||.||:|.:.||||||||||||||.|||||||||:|||||.|||...||.:..
Frog   259 QHFESQQVLENKWSTELQQLSTIQKQEYQEWVIKLHHDLKNPNNSSISEEIKFQPSSLHESADTS 323

Human   261 GRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYSTSL 325
            ...|||.|:|||||||||||||||||||||:||||||||||||||..||||||||||:|||||||
Frog   324 REAYEEHRQLEESFTIHLGAQLKTMHNLRLMRADMLDFCKHKRNHHRGVKLHRLQTAMSLYSTSL 388

Human   326 CGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLDSG 390
            |||||||||||||||||||||||||||||||.||:::||||:||||:||||.||....|...||.
Frog   389 CGLVLLVDNRINSYSGIKRDFATVCQECTDFQFPQLQEQLEIVQQVLLYARAQRDQMSKPQHDST 453

Human   391 NQNGGNDDKTKNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKSGNITARDPAIMGLRN 455
            |.|.|..||.|:   |..|:||||||:||||||||:||.|||||||.|:||||||||||||||||
Frog   454 NGNEGRADKVKS---NQSNLLPGEFYVTRHSNLSEMHVVFHLCVDDSVRSGNITARDPAIMGLRN 515

Human   456 ILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQFLV 520
            |||||||||||||:|||||||:||||||||||.:||||||||||||||||.|||||:||||||||
Frog   516 ILKVCCTHDITTINIPLLLVHEMSEEMTIPWCSKRAELVFKCVKGFMMEMVSWDGGVSRTVQFLV 580

Human   521 PQSISEEMFYQLSNMLPQIFRVSSTLTLTSKH 552
            ||:|||||||||||||||||||||||||||||
Frog   581 PQNISEEMFYQLSNMLPQIFRVSSTLTLTSKH 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C12orf4	NP_001291740.1	DUF2362	41..546	CDD:313393	403/504 (80%)
C12orf4	NP_001291740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..403		9/19 (47%)
c12orf4	XP_012814318.1	DUF2362	104..606	CDD:370836	403/504 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	831	1.000	Domainoid score	I1092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	883	1.000	Inparanoid score	I3812
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52561
OrthoDB	1	1.010	-	-		D100824at32523
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto157391
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110