DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C12orf4 and CG9986

DIOPT Version :9

Sequence 1:	NP_001291740.1	Gene:	C12orf4 / 57102	HGNCID:	1184	Length:	552	Species:	Homo sapiens
Sequence 2:	NP_651623.1	Gene:	CG9986 / 43386	FlyBaseID:	FBgn0039589	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	199/556 - (35%)
Similarity:	304/556 - (54%)	Gaps:	42/556 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    11 REREFVYKFK--VGSQCLELRVPLKFPV-QENASHLHGRLML---LHSLPCFIEKDLK--EALTQ 67
            |...||||:|  .|..| |.|:.:.||. |||......:||.   :..:..::::::|  ..|.:
  Fly     7 RTLPFVYKYKNHKGQDC-ESRLDITFPFDQENLEECITQLMAPNQMDPMMRYLDENIKLERELQK 70

Human    68 FIEEESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYHDL 132
            |::.|..:..|..||..|....:.|:|:..:.....:.|.|..|:.|....||..:.||..:|.|
  Fly    71 FVDTEQQNFLDDQAEKLLKQAANEEMDIEAIVRDTERLYKEELLQFADRVGPSDADIFAQSFHRL 135

Human   133 IHSPASETLLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQH 197
            :||.:.|.:|..|..|...:|::....|.|::.|...|..||:..:.:|..:.|.:|:|:|.||.
  Fly   136 VHSSSLEDILKRERAYAKVVSDMTDLMDSEVETLNNSQQQEMDSQINQLDITTTSEDINNLLAQQ 200

Human   198 FESQQDLENKWSNELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQF----RESVE 258
            :.:|..:..::.:||:.....||.||:.|:           .|.:|:..:|.|...    |.|:
  Fly   201 YTTQNYVRKRYESELEAMMGHQKNEYRNWI-----------TSQVSQMFQVSPVATPLGNRSSM- 253

Human   259 AIGRIYEEQRKLEESFTIHLGAQLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYST 323
                ...:|..:|||||||||:|||.|||:|:|.|::.:.|.......|   |:.|..||.|||:
  Fly   254 ----FVSQQPSMEESFTIHLGSQLKHMHNIRILSANVTELCSPLHAEES---LNGLNMALGLYSS 311

Human   324 SLCGLVLLVDNRINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLD 388
            ||||:|:|..: |.:.:  .::......:.|:|||.:|:.|:|.:::.:....|:..|....|..
  Fly   312 SLCGVVVLTPS-IQAQA--NKNIIKNANKSTEFHFEQIDVQMEKIEKQIKNLTTEDSSGSSTSNS 373

Human   389 SGNQNGGNDDKTKNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKS-GNITARDPAIMG 452
            |...:|......|:..|    :..|:|:||:|||||:.||.|||..|:.:.| ..|.:|.|.|:|
  Fly   374 SAEGSGTPSPTKKSVPR----LKTGDFFITKHSNLSQTHVIFHLISDEPINSPSEINSRHPVILG 434

Human   453 LRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGISRTVQ 517
            ||||||....|||||::||.||.|:|||:||:.||:|||||||||.||||:|.|||.|....|:|
  Fly   435 LRNILKTASRHDITTLTIPALLRHEMSEDMTVQWCIRRAELVFKCAKGFMIESASWGGAELSTLQ 499

Human   518 FLVPQSISEEMFYQLSNMLPQIFRVSSTLTL--TSK 551
            .|:|..|||.:|..|:.|:|.:|.|::...|  |||
  Fly   500 LLLPDDISESLFTTLAGMVPSVFHVANPKILVDTSK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C12orf4	NP_001291740.1	DUF2362	41..546	CDD:313393	180/514 (35%)
C12orf4	NP_001291740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..403		4/19 (21%)
CG9986	NP_651623.1	DUF2362	44..528	CDD:287163	180/509 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159956
Domainoid	1	1.000	305	1.000	Domainoid score	I1373
eggNOG	1	0.900	-	-		E1_KOG4506
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2555
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52561
OrthoDB	1	1.010	-	-		D285902at33208
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto91534
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800