Protein Alignment C12orf4 and C55A6.10

DIOPT Version :9

• Sequence 1: NP_001291740.1
• Gene: C12orf4 / 57102
• HGNCID: 1184
• Length: 552
• Species: Homo sapiens
• Sequence 2: NP_001360533.1
• Gene: C55A6.10 / 179581
• WormBaseID: WBGene00008339
• Length: 549
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 159/546 - (29%)
• Similarity: 267/546 - (48%)
• Gaps: 65/546 - (11%)

Human    26 LELRVPLKFPVQENASHLHGRLMLLHSLPC--FIE-KDLKEALTQFIEEESLSDYDRDAEASL-- 85
            :.::||:..|   ..|:|...:..|.:.|.  |:: :..||||.:||..|:::..:|...:::
 Worm    34 VRIQVPIPLP---EYSYLEDWVGKLRAQPSGKFLDYEGAKEALRKFIYSETINHQNRRTISNIEC 95

Human    86 AAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYHDLIHSPASETLLNL-EHNYF 149
            |..|..|:.:    ..:..:.....||..|.....::|.|..|    :...:||.||.| ....|
 Worm    96 AVKKKREMGM----PLFQPSRNRRLLEPRRKPVVPFEEKFTYV----VEQSSSENLLTLMRMEVF 152

Human   150 V--SISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHF-ESQQDLENKWSNE 211
            :  .::::|..|:.|:.:|.:    :.||::.|.|    |.|::....... |..:.:...:|.:
 Worm   153 MKKQMTDMIRARNWEVDQLSK----QCEKLVAETG----DPDMHPHKISMLNEKLRQVHTTYSFQ 209

Human   212 LKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESVEAIGRIYEEQRKLEESFTI 276
            :...:..||.:|::.|..|:.....|  :.|.:::.:........|......|.:  .:.|||||
 Worm   210 VADLSDTQKSKYRKAVDSLYSRGSIP--AELLDDVILDEHAIPRPVATTTGGYAD--GVNESFTI 270

Human   277 H--LGAQLKTMHNLRLLRADML-DFCKHKRNHRSGVKLHRLQTALSLYSTSLCGLVLLVDN---- 334
            :  :|:|||:|||:.|:..|.| |.|:....  ......||:.|..|||.:|.|..|||..
 Worm   271 YIAIGSQLKSMHNVCLVTVDRLTDLCQTLEG--DWTTSSRLEMATKLYSRNLSGTTLLVPRDPMM 333

Human   335 RINSYSGIKRDFATVCQECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLDSGNQNGGNDDK 399
            .|||.|    ||..:|::.||.||..:.|||    :..|.|..:|.|...:.:|........:.|
 Worm   334 HINSSS----DFFKICEQSTDLHFDSLAEQL----KKTLAANRERNSWKADKIDEETSKLIAEGK 390

Human   400 T-------KNAERNYLNVLPGEFYITRHSNLSEIHVAFHLCVDDHVKSGNITARDPAIMGLRNIL 457
            |       .:|.|.......|:.||||||||.::.:.:||.||:.::|..|.:|.|.:.|:|||:
 Worm   391 TPPEQLVPSSALRQDPTCTVGDVYITRHSNLHKVQIVYHLVVDETLQSLEINSRHPCLAGVRNII 455

Human   458 KVCCTHDITTISIPLLLVHDMSEEMTIPWCLRRAELVFKCVKGFMMEMASWDGGIS------RTV 516
            :....::.:||.|||||:....|..||.|||:|||::||||||::||:.|   |:.      ..|
 Worm   456 RTAARYNTSTIHIPLLLIDRPDESTTIAWCLKRAEMLFKCVKGYLMEVCS---GMDVESLPHYNV 517

Human   517 QFLVPQSISEEMFYQLSNMLPQIFRV 542
            .|::|..:|..::..::||.|.||.:
 Worm   518 HFVLPSGLSPTIYTAITNMFPSIFHL 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C12orf4	NP_001291740.1	DUF2362	41..546	CDD:313393	156/531 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..403		3/26 (12%)
C55A6.10	NP_001360533.1	DUF2362	49..547	CDD:370836	154/528 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161471954
Domainoid	1	1.000	180	1.000	Domainoid score	I2339
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10685
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3009
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285902at33208
OrthoFinder	1	1.000	-	-		FOG0007202
OrthoInspector	1	1.000	-	-		oto21517
orthoMCL	1	0.900	-	-		OOG6_106014
Panther	1	1.100	-	-	LDO	PTHR16525
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3086
SonicParanoid	1	1.000	-	-		X5311
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930