DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLSCR4 and scramb2

DIOPT Version :9

Sequence 1:	NP_001121776.1	Gene:	PLSCR4 / 57088	HGNCID:	16497	Length:	329	Species:	Homo sapiens
Sequence 2:	NP_647761.1	Gene:	scramb2 / 38362	FlyBaseID:	FBgn0035390	Length:	263	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	106/272 - (38%)
Similarity:	148/272 - (54%)	Gaps:	23/272 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    56 LPMGYYSPQQPSTFPLYQP----VGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYL 116
            ||..  :||..:...:.||    ||.              |.:.|..||..|..|.|||.|||||
  Fly    10 LPQN--APQDENGAVVLQPQAANVGN--------------NANGPENWMSIPVGMPNCPQGLEYL 58

Human   117 VQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDC 181
            ..||.:.|.|..|.||::|.|||.||:.:||:..|.||...|::|..|||.....|||.:::.|.
  Fly    59 TALDQLLVSQKIEKLELLTGFETKNRFKVKNSLGQNVYFAYEESDCCTRNMLGRSRPFEMKILDN 123

Human   182 MGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRV 246
            ...|::.:.|||:|...| |.||....:||..|||..||.|.:.....|..::|:|...:.|:::
  Fly   124 FQNEVLHLYRPFKCDILC-CFPSCMNAVEVSAPPGQVIGSVEQVCTFMRPKFNIKNTCGDTVLQI 187

Human   247 RGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGL-LSAMADADHFDIHFPLDLDVKMKAMIFG 310
            .||.....|.||:.|:|.|.:. ..||.|.::|:|| .....|||:|.:.|||:|||:|||:||.
  Fly   188 EGPVCPCKCFSDTNFKVLSANN-EEIGKISKQWSGLGRELFTDADYFSVTFPLNLDVRMKALIFA 251

Human   311 ACFLIDFMYFER 322
            |.||||.:|:|:
  Fly   252 ALFLIDAVYYEQ 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLSCR4	NP_001121776.1	Proline-rich domain (PRD). /evidence=ECO:0000250	1..98		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		SH3-binding 1. /evidence=ECO:0000255	18..25
		PPxY motif. /evidence=ECO:0000255	30..33
		Atrophin-1	<36..100	CDD:331285	10/47 (21%)
		SH3-binding 2. /evidence=ECO:0000255	41..49
		SH3-binding 3. /evidence=ECO:0000255	98..106		3/7 (43%)
		Scramblase	100..322	CDD:252175	94/222 (42%)
scramb2	NP_647761.1	Scramblase	42..263	CDD:252175	94/222 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880