DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX20 and tbx20

DIOPT Version :9

Sequence 1:	NP_001071121.1	Gene:	TBX20 / 57057	HGNCID:	11598	Length:	447	Species:	Homo sapiens
Sequence 2:	NP_001030292.1	Gene:	tbx20 / 619590	XenbaseID:	XB-GENE-487334	Length:	440	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	401/447 - (89%)
Similarity:	425/447 - (95%)	Gaps:	7/447 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLEQFVEKSSCAQPLGELTSLDAHG 65
            ||:|.||||||||||||||||||||||..|:||..|:||||||||||||||:||||:::.:|:||
Frog     1 MEYTPSPKPQLSSRANAFSIAALMSSGTPKDKETQESTIKPLEQFVEKSSCSQPLGDISIVDSHG 65

Human    66 EFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMF 130
            ||      :.|.|||||||||||||:|||||||||:|||||||||||||:|||||||||||||||
Frog    66 EF------TNSPSSLCTEPLIPTTPVIPSEEMAKISCSLETKELWDKFHDLGTEMIITKSGRRMF 124

Human   131 PTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQ 195
            |||||||||||.:||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   125 PTIRVSFSGVDADAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQ 189

Human   196 LLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETV 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Frog   190 LLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFQETV 254

Human   261 FTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLG 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||| |:|||||
Frog   255 FTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTY-GDEDVLG 318

Human   326 DESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPY 390
            ::.||..:||||||||:||||||||||:|.|.|||||||||||||||||:||||||||||:||||
Frog   319 EDGQTMQSRGSAFTTSENLSLSSWVSSTSGFSGFQHPQSLTALGTSTASLATPIPHPIQGTLPPY 383

Human   391 SRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV 447
            ||||||:||||:|||||||||||||||||||||||||||||||||||||||||||||
Frog   384 SRLGMPITPSALASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..81		8/18 (44%)
		T-box	102..288	CDD:307177	181/185 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		15/23 (65%)
		DUF853	<357..>409	CDD:331106	46/51 (90%)
tbx20	NP_001030292.1	T-box	96..282	CDD:366363	181/185 (98%)
tbx20	NP_001030292.1	T-box	98..282		179/183 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	375	1.000	Domainoid score	I6660
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32476
Inparanoid	1	1.050	806	1.000	Inparanoid score	I4380
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43805
OrthoDB	1	1.010	-	-		D108352at32523
OrthoFinder	1	1.000	-	-		FOG0004466
OrthoInspector	1	1.000	-	-		oto148260
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2836
SonicParanoid	1	1.000	-	-		X2653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110