Protein Alignment TBX20 and mid

DIOPT Version :10

• Sequence 1: NP_001071121.1
• Gene: TBX20 / 57057
• HGNCID: 11598
• Length: 447
• Species: Homo sapiens
• Sequence 2: NP_608927.2
• Gene: mid / 33770
• FlyBaseID: FBgn0261963
• Length: 580
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 200/501 - (39%)
• Similarity: 271/501 - (54%)
• Gaps: 121/501 - (24%)

Human     4 TASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLE-------QFVEKSSCAQPLGELTSL 61
            |.:.....:..|..|||||:|:...:..:|::..:..|:.       ..|:.|...:|..:...|
  Fly    27 TTTASKSAAGSATDFSIAAIMAREDASSRESSIRSASPISVEDEVDVDVVDCSDAEEPPTKARRL 91

Human    62 DAHGEF-------------------------GGG-----------SGSSPSSSSLCTEPLIPTTP 90
            :.|...                         ||.           :.||.||...|:.|  |.:|
  Fly    92 NHHQHHQHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTP--PQSP 154

Human    91 -------------------IIPS---EEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTI 133
                               |:.|   :::..:.|.||||||||:||:|||||||||:|||||||:
  Fly   155 GTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTV 219

Human   134 RVSFSG----VDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGE 194
            ||||||    :.|..:|.|||||:|:|:||||||||||:|||||||||..|||||.||||||:.|
  Fly   220 RVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCE 284

Human   195 QLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASL----LNLKSEEFRTFI 255
            .|.||::|||||||||||:|::|.|:|||||:||||:|:: :..|..|:    ..|:..:.:|::
  Fly   285 ALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLV-RLSHGQSIPSNPKELQDLDHKTYV 348

Human   256 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGE 320
            |||||||||||||||||||||||||||||||||||||||.:|:.:|:|:.:.. .|||:|.:
  Fly   349 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMEALLLEQQ-LRSPLRLF--- 409

Human   321 EDVLGDE--SQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPI 383
            .|.|..:  :|..|:..:.|..:.                 ||.|..
  Fly   410 PDPLMQQFAAQGDPSSMALFEKAR-----------------QHLQMF------------------ 439

Human   384 QGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGP 429
             |...||::|.||....|.|::   :||..|...:..:|.:.||.|
  Fly   440 -GGNSPYAQLMMPQMYQAAAAA---AGPPPPPPGLGAFHMFQQQWP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..81		7/54 (13%)
		T-box_TBX20-like	100..289	CDD:410319	136/196 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		5/25 (20%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<337..>409	CDD:476819	12/71 (17%)
mid	NP_608927.2	T-box_TBX20-like	186..382	CDD:410319	136/196 (69%)