DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TBX20 and mid

DIOPT Version :9

Sequence 1:	NP_001071121.1	Gene:	TBX20 / 57057	HGNCID:	11598	Length:	447	Species:	Homo sapiens
Sequence 2:	NP_001260096.1	Gene:	mid / 33770	FlyBaseID:	FBgn0261963	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	200/501 - (39%)
Similarity:	271/501 - (54%)	Gaps:	121/501 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     4 TASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLE-------QFVEKSSCAQPLGELTSL 61
            |.:.....:..|..|||||:|:...:..:|::..:..|:.       ..|:.|...:|..:...|
  Fly    27 TTTASKSAAGSATDFSIAAIMAREDASSRESSIRSASPISVEDEVDVDVVDCSDAEEPPTKARRL 91

Human    62 DAHGEF-------------------------GGG-----------SGSSPSSSSLCTEPLIPTTP 90
            :.|...                         ||.           :.||.||...|:.|  |.:|
  Fly    92 NHHQHHQHHQHHHNNNNNNNNNNVAHKSRNSGGAVAQTASAESQLNTSSTSSQGRCSTP--PQSP 154

Human    91 -------------------IIPS---EEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTI 133
                               |:.|   :::..:.|.||||||||:||:|||||||||:|||||||:
  Fly   155 GTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGTEMIITKTGRRMFPTV 219

Human   134 RVSFSG----VDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGE 194
            ||||||    :.|..:|.|||||:|:|:||||||||||:|||||||||..|||||.||||||:.|
  Fly   220 RVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAYHRSAWLVAGKADPAPPARLYAHPDSPFSCE 284

Human   195 QLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASL----LNLKSEEFRTFI 255
            .|.||::|||||||||||:|::|.|:|||||:||||:|:: :..|..|:    ..|:..:.:|::
  Fly   285 ALRKQVISFEKVKLTNNEMDKNGQIVLNSMHRYQPRIHLV-RLSHGQSIPSNPKELQDLDHKTYV 348

Human   256 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGE 320
            |||||||||||||||||||||||||||||||||||||||.:|:.:|:|:.:.. .|||:|.:
  Fly   349 FPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDFDRDPMEALLLEQQ-LRSPLRLF--- 409

Human   321 EDVLGDE--SQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPI 383
            .|.|..:  :|..|:..:.|..:.                 ||.|..
  Fly   410 PDPLMQQFAAQGDPSSMALFEKAR-----------------QHLQMF------------------ 439

Human   384 QGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGP 429
             |...||::|.||....|.|::   :||..|...:..:|.:.||.|
  Fly   440 -GGNSPYAQLMMPQMYQAAAAA---AGPPPPPPGLGAFHMFQQQWP 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..81		7/54 (13%)
		T-box	102..288	CDD:307177	135/193 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		5/25 (20%)
		DUF853	<357..>409	CDD:331106	11/51 (22%)
mid	NP_001260096.1	TBOX	185..384	CDD:238106	138/199 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141531
Domainoid	1	1.000	286	1.000	Domainoid score	I1609
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004466
OrthoInspector	1	1.000	-	-		oto88516
orthoMCL	1	0.900	-	-		OOG6_107249
Panther	1	1.100	-	-	LDO	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2836
SonicParanoid	1	1.000	-	-		X2653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780