Protein Alignment TBX20 and H15

DIOPT Version :10

• Sequence 1: NP_001071121.1
• Gene: TBX20 / 57057
• HGNCID: 11598
• Length: 447
• Species: Homo sapiens
• Sequence 2: NP_608926.2
• Gene: H15 / 33769
• FlyBaseID: FBgn0016660
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 211/592 - (35%)
• Similarity: 279/592 - (47%)
• Gaps: 191/592 - (32%)

Human    13 SRANAFSIAALMSSGGS--KEKEATENTIKP--LEQF----------VEKSSCAQPLGELTSLDA 63
            |.|..|||||:|:.||:  ..:|.:|.::.|  :|::          |:...|:.  .|:.|..|
  Fly    76 SFATDFSIAAIMARGGNAPSSREPSERSLSPASVERYSGQDADDDVDVDVVDCSD--SEMPSATA 138

Human    64 ---------------------------------------------HGEFG--------------- 68
                                                         |...|
  Fly   139 AAAAAATTAAAAAAALQAQQQARQALRVAQQQQQQQQQQRQQTHHHATTGKQQRQHHNHHSSNTN 203

Human    69 --GGSGSS-----------------------------PSSSSLCTEPLI--------PTTPIIPS 94
              ..||:|                             ||.|....|.|.        ||..|:.|
  Fly   204 NSSNSGNSNTNSKSSSQRGRSAAAVGAAATPSPPPPPPSQSPEELERLSPEESPAQQPTPKIVGS 268

Human    95 ---EEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSG----VDPEAKYIVLMDI 152
               :::..:.|.|||||||||||||||||||||||||||||:||||||    :.|..:|.||:|:
  Fly   269 CNCDDLTPVQCHLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGPLRQIQPADRYAVLLDV 333

Human   153 VPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHG 217
            ||:|::||||||||||||||||||||.|:|:|.|||.|.:.|.|.||:||||||||||||:|:.|
  Fly   334 VPLDSRRYRYAYHRSSWLVAGKADPPPPSRIYAHPDCPLSPEALRKQVVSFEKVKLTNNEMDKSG 398

Human   218 HIILNSMHKYQPRVHIIKKKDHTASL----LNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKID 278
            .::|||||:||||:|:: :..|..|:    ..|:..:.:||:|||||||||||||||||||||||
  Fly   399 QVVLNSMHRYQPRIHLV-RLSHGQSIPGSPKELQDMDHKTFVFPETVFTAVTAYQNQLITKLKID 462

Human   279 SNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGDESQTTPNRGSAFT---- 339
            ||||||||||||||:|.:|:.:::.........:|:|.:   .|.|  .||.||....|.:
  Fly   463 SNPFAKGFRDSSRLSDFDRDPMDAFFFDQHMRTAPLRFF---PDPL--MSQLTPQEADAASMALL 522

Human   340 ----------------------------------TSDNLSL-------SSWVSSSSSFPGFQHPQ 363
                                              .:.:||.       ..|...::.|....:.|
  Fly   523 EKARQHLQMFGRSPYTEMLLPHLYQRSAAPPPPPPAPHLSAFQLGMWQQQWPQLTAGFLASANQQ 587

Human   364 SLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQ- 427
            :..||   .|:.|...|.|.....||     .|.||:   ||...:.|...:  .|:.:||.|:
  Fly   588 AALAL---AAAGANRTPPPSMAVAPP-----APATPT---SSCGSASPDLRA--RPQLNHYPQRF 639

Human   428 GPYAAIQ 434
            .||...|
  Fly   640 SPYQVPQ 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBX20	NP_001071121.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..81		9/109 (8%)
		T-box_TBX20-like	100..289	CDD:410319	136/196 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		7/61 (11%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<337..>409	CDD:476819	19/116 (16%)
H15	NP_608926.2	T-box_TBX20-like	277..473	CDD:410319	136/196 (69%)