Protein Alignment PSMC5 and Gk1

DIOPT Version :10

• Sequence 1: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_524655.1
• Gene: Gk1 / 43913
• FlyBaseID: FBgn0025592
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 88/464 - (18%)
• Similarity: 152/464 - (32%)
• Gaps: 161/464 - (34%)

Human    26 SKIEELQLIVNDKSQNLRRLQ------AQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKK 84
            |.:|||...:.:.::|:..|:      ........|:|.||:.:.:          |.:||:|..
  Fly   128 STVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPV----------VSQAMEKGT 182

Human    85 VLVKVHPEGKFVVDV----------DKNIDINDVTPNCRVALRN------DSYTLHKI-LPNKVD 132
            .:..       .:|.          |..:...|||...|..|.|      |:..|... ||..:.
  Fly   183 AMFG-------TIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTIL 240

Human   133 PLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKG----VLLYGPPG 193
            |.:.         |:.|..|.:.:.:                .:.:||....|    .|:
  Fly   241 PEIC---------SSSEFYGSIAQGV----------------LQGIGITSVLGDQQAALV----- 275

Human   194 TGKTLLARAVA---HHTDCTFIRVSGSELVQKFIG----EGARMVRELF-VMAREHAPSII---- 246
             |:..||:..|   :.|.|..:..:|..:|....|    .|.::.|:.. ..|.|.:.||.
  Fly   276 -GQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAF 339

Human   247 --FMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGF-------------------------E 284
              ..|.::.|.:|       |..|...:.::  |.||.:                         |
  Fly   340 NWLRDNMNLIQNS-------GQIETMASTVD--NSLDVYFVPAFNGLYAPYWNQDARGVICGLSE 395

Human   285 ATKNIKVIMATNRI------DILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGIN 343
            .|.:..::.||...      |||||.     ..|.||.......:..:.:..:..:..:...||.
  Fly   396 ETTSEHIVRATLEAVCFQVRDILDSM-----HKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQ 455

Human   344 L--RKIAELMP-GASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKD--------SEK 397
            :  .||||... ||:.|..|.|          |.|..:     |..::|...::        :::
  Fly   456 VLRAKIAETTALGAAMAAYKAV----------ENRYQM-----EAPLSKSGPREAIKPSISATDR 505

Human   398 NMSIKKLWK 406
            |:..:| ||
  Fly   506 NLRYQK-WK 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	85/456 (19%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		53/275 (19%)
Gk1	NP_524655.1	ASKHA_NBD_FGGY_GK1-3-like	18..519	CDD:466802	88/464 (19%)