Protein Alignment PSMC5 and kat-60L1

DIOPT Version :10

• Sequence 1: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001163523.1
• Gene: kat-60L1 / 40715
• FlyBaseID: FBgn0037375
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 414
• Identity: 131/414 - (31%)
• Similarity: 200/414 - (48%)
• Gaps: 88/414 - (21%)

Human    38 KSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKN 102
            ||:::.||:|::...|.::.|                             |..|..|..:|.:.|
  Fly   295 KSRSVERLRARKLSTNTQLNL-----------------------------KHKPVKKNSLDENSN 330

Human   103 IDINDVTPNCRVALRNDSY-----TLH-------KILPNKVDPL---VSLM------MVEKVPDS 146
            .|..|.|    .:|.::|:     |.|       |.......||   |.|:      ::::.|..
  Fly   331 SDDQDAT----TSLEDNSHAQSLATSHNTPKCSPKTKAKHFSPLGYEVHLVDTLEKDILQRHPCI 391

Human   147 TYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQP-KGVLLYGPPGTGKTLLARAVAHHTDCT 210
            .:..:.||::....::|.:.|||..||.|:  ||.:| :|||:.||||||||:||:|||.....|
  Fly   392 KWTDVAGLNEAKTILQEAVVLPVIMPEFFK--GIRRPWRGVLMVGPPGTGKTMLAKAVATECGTT 454

Human   211 FIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSE---VQRT 272
            |..||.|.|..|:.||..::||.||.|||.:|||.||:||||::.:||     |.|||   .:|.
  Fly   455 FFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDALCASR-----GSDSEHEASRRF 514

Human   273 MLELLNQLDGFEAT----KNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHS 333
            ..|||.|:||..|:    |.|.|:.|||....:|.|..|  |.:::|..|.|||..|..:||:..
  Fly   515 KAELLIQMDGLNASMQEEKVIMVLAATNHPWDIDEAFRR--RFEKRIYIPLPNEGTRSALLKLCL 577

Human   334 RKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE-------------RRVHVTQ----E 381
            :.:.|:..:|...|.:.:.|.||:::..||.:|.|.|:|.             ||..|.|    :
  Fly   578 KDVCLSPSLNTGIIGDELQGYSGSDISNVCRDASMMAMRRLISGRTPDQIKQIRREEVDQPITLQ 642

Human   382 DFEMAVAKVMQKDSEKNMSIKKLW 405
            ||:.|..:..:..|..:::..:.|
  Fly   643 DFQDARLRTKKSVSADDVARFEKW 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	130/407 (32%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		93/244 (38%)
kat-60L1	NP_001163523.1	P-loop containing Nucleoside Triphosphate Hydrolases	395..561	CDD:476819	78/174 (45%)
		AAA_lid_3	591..629	CDD:465537	10/37 (27%)
		Vps4_C	<638..671	CDD:462762	5/29 (17%)