Protein Alignment PSMC5 and Gk2

DIOPT Version :10

• Sequence 1: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_647655.1
• Gene: Gk2 / 38221
• FlyBaseID: FBgn0035266
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 67/336 - (19%)
• Similarity: 119/336 - (35%)
• Gaps: 76/336 - (22%)

Human    53 NAKVRLLREELQ---LLQEQGSYVGEVVRAMDK--KKVLVKVHPEGKFVVDVDKNIDINDVTPNC 112
            :|.|....:||:   |:|..|     :|..:|:  |.:...::....|.......::::.:||
  Fly    11 SADVPFRSKELRKQSLIQHTG-----LVGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITP-- 68

Human   113 RVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKE-IKEVIELPVKHPELFE 176
                 .|.:       .:.|||              ||:..::|..:| ||::.|......::.
  Fly    69 -----QDGW-------YEQDPL--------------EMMASINKCAEEAIKQLPEQGFSASDIV- 106

Human   177 ALGIAQPKGVLLYGPPGTGK--------------TLLARAVAHHTDCTFIRVSGSELVQKFIGEG 227
            .:||...:...:.....|||              |.:.:.||...|....|.|....:..:.  .
  Fly   107 TVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKVQDPNHFRSSTGLPISTYF--S 169

Human   228 ARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVI 292
            |..:|.|    |::.|.:     ..:|...|.:.|:.....|.......|:..|...|::.:.:.
  Fly   170 ALKIRWL----RDNVPEV-----RQAIRERRCKAGTVDSWIVWNLTNGALHITDVTNASRTLLMN 225

Human   293 MATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGA 357
            :.|   ...|..||:...|  :.|..|..........||.|.:..| ||:.|..|.    |...|
  Fly   226 LET---QAWDPVLLKTFGI--REEMLPTIHSCSEIFGKITSERSPL-RGMTLSGIM----GNQQA 280

Human   358 EVKG-VCTEAG 367
            .:.| :|.:.|
  Fly   281 SLLGQMCVKPG 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	67/336 (20%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		41/197 (21%)
Gk2	NP_647655.1	glycerol_kin	31..533	CDD:273549	61/316 (19%)