Protein Alignment PSMC5 and YME1L

DIOPT Version :10

• Sequence 1: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Alignment Length: 268
• Identity: 106/268 - (39%)
• Similarity: 155/268 - (57%)
• Gaps: 12/268 - (4%)

Human   130 KVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGT 194
            :|||       |:: :.|:|.:.|.|:..:|:|||:|. :|.||.|..||...||||||.|||||
  Fly   293 EVDP-------EEI-NVTFEDVKGCDEAKQELKEVVEF-LKSPEKFSNLGGKLPKGVLLVGPPGT 348

Human   195 GKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRL 259
            ||||||||||......|...:|.|..:..:|:|||.||:||..|:..||.:||:|||||:|:.|.
  Fly   349 GKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRT 413

Human   260 EGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEA 324
              .|.......:|:.:||:::|||.....:.|:.||||.|.||.|||||||.|.::....|:...
  Fly   414 --NSVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTG 476

Human   325 RLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAK 389
            |.:||.::..|: |...|:|..:|....|.:||:::.:..:|.:.|..:....|:.:..|.|..|
  Fly   477 RKEILSLYLTKI-LHDEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDK 540

Human   390 VMQKDSEK 397
            |:.....|
  Fly   541 VLMGPERK 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	106/268 (40%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		84/212 (40%)
YME1L	NP_001246473.1	HflB	258..737	CDD:440233	106/268 (40%)