Protein Alignment PSMC5 and Spg7

DIOPT Version :10

• Sequence 1: NP_002796.4
• Gene: PSMC5 / 5705
• HGNCID: 9552
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_570017.1
• Gene: Spg7 / 31253
• FlyBaseID: FBgn0024992
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 385
• Identity: 125/385 - (32%)
• Similarity: 197/385 - (51%)
• Gaps: 62/385 - (16%)

Human    55 KVRLLREELQ----LLQEQGSYVGEVVRAMDKKKVL--VKVHPEGKF---VVDVDKNIDINDVTP 110
            |..::|.:::    :|.|     |.|::.......:  :.|....||   :.||:|.:.|.|..|
  Fly   217 KELIIRPDMEMVTIILHE-----GAVIKGRKVSSTIFHMAVADANKFEEKLRDVEKRLGIKDGVP 276

Human   111 NCRVALRNDSYTLHKILPNKVDPLVSLMMVE--------KVP---DSTYEM-------------- 150
               |.....:.|..:||   :..||..:::.        |.|   ||..:|
  Fly   277 ---VTYDRQTDTTGRIL---MLLLVCALLMSIATRMKSIKSPLSMDSFNQMGRAKFTLVDPFDGG 335

Human   151 -------IGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTD 208
                   :.||.:..:|:||.::. :|.||.::.||...|:|.||.||||.||||||:|||....
  Fly   336 RGVLFRDVAGLSEAKQEVKEFVDY-LKSPEKYQRLGAKVPRGALLLGPPGCGKTLLAKAVATEAQ 399

Human   209 CTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSR-----LEGGSGGDSE 268
            ..|:.::|||.::...|.||..||:||...::.||.||::||||:||..|     :..||.|:||
  Fly   400 VPFLSMNGSEFIEMIGGLGAARVRDLFKEGKKRAPCIIYIDEIDAIGRQRSGTESMGQGSSGESE 464

Human   269 VQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIH- 332
              :|:.:||.::||....:.:.::.:|||.||||.|||||||.||.|....|....|.:|.:.|
  Fly   465 --QTLNQLLVEMDGMATKEGVLMLASTNRADILDKALLRPGRFDRHILIDLPTLAERKEIFEKHL 527

Human   333 -SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVM 391
             |.|:........:::|.|.||.|||::..||.||.::|.|..::.|:.::.|.||.:::
  Fly   528 SSVKLESPPTTFSQRLARLTPGFSGADIANVCNEAALHAARNTQMEVSSKNLEYAVERLV 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSMC5	NP_002796.4	PRK03992	24..400	CDD:179699	125/385 (32%)
		May mediate interaction with PRPF9. /evidence=ECO:0000250|UniProtKB:P62196	186..406		87/213 (41%)
Spg7	NP_570017.1	HflB	178..788	CDD:440233	125/385 (32%)