Protein Alignment SLC17A7 and FEN2

DIOPT Version :10

• Sequence 1: NP_064705.1
• Gene: SLC17A7 / 57030
• HGNCID: 16704
• Length: 560
• Species: Homo sapiens
• Sequence 2: NP_009957.1
• Gene: FEN2 / 850394
• SGDID: S000000623
• Length: 512
• Species: Saccharomyces cerevisiae
• Alignment Length: 572
• Identity: 108/572 - (18%)
• Similarity: 179/572 - (31%)
• Gaps: 208/572 - (36%)

Human    51 VVDCTCFGLPRRYIIAIMSGLGFCISF--GIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDP 113
            |:...|.    :|.|..:..:||..::  |::.:|     .||.|..|
Yeast    37 VLSFVCL----QYWINYVDRVGFTNAYISGMKEDL-----KMVGNDLT----------------- 75

Human   114 ETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRIL 178
                :.:..|..||||..:|...:...........|...|...|.:.:.......:.|.|  |..
Yeast    76 ----VSNTVFMIGYIVGMVPNNLMLLCVPPRIWLSFCTFAWGLLTLGMYKVTSFKHICAI--RFF 134

Human   179 QGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQ-----------YS 232
            |.|.|..|:...|.:...|... :...:.:..|.||  |.|.:| .:|.:..           .:
Yeast   135 QALFESCTFSGTHFVLGSWYKE-DELPIRSAIFTGS--GLVGSM-FSGFMQTSIFTHLNGRNGLA 195

Human   233 GWSSVFY----------VYG---------------SFGIFWYLFWLLVSYESPALHPSISEEERK 272
            ||..:|.          :||               .|.:..|:|               :|:|..
Yeast   196 GWRWLFIIDFCITLPIAIYGFIFFPGLPDQTSAVSKFSMTRYIF---------------NEQELH 245

Human   273 YIE---DAIGESAKL-MNPLTKFSTPWRRFFTSMPVYAIIVAN--FCRSWTFYLLLISQPAYFEE 331
            |..   .|..||.:| .:.:.:....|..:..|: |:.:...|  |..:.||.|.|.:|.....:
Yeast   246 YARRRLPARDESTRLDWSTIPRVLKRWHWWMFSL-VWVLGGENLGFASNSTFALWLQNQKYTLAQ 309

Human   332 VFGFE--ISKVGLVSAL---------PH-----------LVMTIIVPIGGQIADFLRSRRIMSTT 374
            ...:.  |..||:||.|         |.           |||.|:..:  ..||.|..:.:.|..
Yeast   310 RNNYPSGIFAVGIVSTLCSAVYMSKIPRARHWHVSVFISLVMVIVAVL--IRADPLNPKVVFSAQ 372

Human   375 NVRKLMNCGGFGMEATLLLVVGYSHSKGVAISF---------------LVLAV--GFSGFAISGF 422
            .:      ||          |.|:   |.|:.|               :|||.  .|||...:.:
Yeast   373 YL------GG----------VAYA---GQAVFFSWANIICHADLQERAIVLASMNMFSGAVNAWW 418

Human   423 NVNHL--DIAPR-----YASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHY 480
            ::...  |:.|:     ||.:...||      ||:|..:|.....|
Yeast   419 SILFFASDMVPKFERGCYALLATAIS------SGIVSVVIRSLQIK------------------- 458

Human   481 GGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAEPPG 532
                                |.:|:::..::..:.:.|.||.:...:.|..|
Yeast   459 --------------------ENLSKKQVPYIDANDMPGEDDDDDNQDNENDG 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC17A7	NP_064705.1	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	97/513 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..560		7/36 (19%)
FEN2	NP_009957.1	MFS_FEN2_like	32..450	CDD:340885	99/491 (20%)