Protein Alignment SLC17A7 and VGlut

DIOPT Version :10

• Sequence 1: NP_064705.1
• Gene: SLC17A7 / 57030
• HGNCID: 16704
• Length: 560
• Species: Homo sapiens
• Sequence 2: NP_608681.2
• Gene: VGlut / 33427
• FlyBaseID: FBgn0031424
• Length: 632
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 264/560 - (47%)
• Similarity: 339/560 - (60%)
• Gaps: 69/560 - (12%)

Human    38 DGRPVT----TQTRDPPV--------VDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSM 90
            |.||.:    .:...||:        .:|.|  :|.||.||.|:.:||.|:||:|||:..|.:..
  Fly    61 DDRPDSPASFEEIERPPLRKIDKYCKAECPC--MPARYTIATMACVGFMIAFGMRCNMSAAKLKG 123

Human    91 VNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATS 155
            .:|.|..           .:|.......:..||||||:|||||||||..||.||::||.:||:::
  Fly   124 EHNGTVF-----------MNWTVAVESHVDSSFFWGYLVTQIPGGFIASKFPANKIFGLSIVSSA 177

Human   156 TLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAV 219
            ||::.:|.|..:.:| .||.||:||||.||||||||||||..||||:|||||||.||.|||||.|
  Fly   178 TLHLFVPFAMTLMHGHVVICVRVLQGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVV 242

Human   220 VAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKL 284
            |.:||:|:|....|:.:.||.||.|||.||:||:.:.:|:|..||:||..|.||||.::||||..
  Fly   243 VGLPLSGLLADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSLGESAHP 307

Human   285 MNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHL 349
            ..|..| :||||....||||||||||||||||.||||::.|.::.:..|||::.:.|.|.:||||
  Fly   308 TMPSLK-TTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKFGFKVEEAGFVGSLPHL 371

Human   350 VMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGF 414
            :||.|||.||.:||.||...|:||||||||.||||||||....|.|.:|.:...|:..|...|.|
  Fly   372 IMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCGGFGMEGLFFLFVAHSSTATGAMFALTCGVAF 436

Human   415 SGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVH 479
            |||||||:|||||||||||||||||:|||:|||:|::.|..:..:.:......|..||.:|:.||
  Fly   437 SGFAISGYNVNHLDIAPRYASILMGLSNGIGTLAGIIVPYALDGLIQANPTGCWTTVFTLAACVH 501

Human   480 YGGVIFYGVFASGEKQPWAEP--EEM-------------SEEKCGFVGHDQLAGS-------DDS 522
            ..|..|||:|||||.||||||  ||.             ...:.|.:|......|       :.|
  Fly   502 LVGCTFYGIFASGELQPWAEPPAEEQKVWAPPPGAITNTDPSQAGMLGDYMKETSFGAPEYTEQS 566

Human   523 EMEDE----------------AEPPGAPPA----PPPSYG 542
            :|:..                |...||||.    .||:||
  Fly   567 QMQQSTAISYGATGHVANNPFAMASGAPPIAEEDAPPTYG 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC17A7	NP_064705.1	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	226/424 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..560		20/88 (23%)
VGlut	NP_608681.2	MFS_SLC17A6_7_8_VGluT	99..512	CDD:340940	226/424 (53%)