Protein Alignment SLC17A7 and eat-4

DIOPT Version :10

• Sequence 1: NP_064705.1
• Gene: SLC17A7 / 57030
• HGNCID: 16704
• Length: 560
• Species: Homo sapiens
• Sequence 2: NP_499023.3
• Gene: eat-4 / 176291
• WormBaseID: WBGene00001135
• Length: 576
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 262/549 - (47%)
• Similarity: 350/549 - (63%)
• Gaps: 28/549 - (5%)

Human     9 RKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDP---PVVDCTCFGLPR-RYIIAIMS 69
            :::.|..|.|:..........|...::..:|.....|....   .|::.|..|..| |:::||::
 Worm    12 KQMVGEPLAKMTAAAASATGAAPPQQMQEEGNENPMQMHSNKVLQVMEQTWIGKCRKRWLLAILA 76

Human    70 GLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFSWDPETVGLIHGSFFWGYIVTQIPG 134
            .:||.||||||||.|.|...|..|.|...|   .|...:|:|..:.:.::..|:|:||:|||||.
 Worm    77 NMGFMISFGIRCNFGAAKTHMYKNYTDPYG---KVHMHEFNWTIDELSVMESSYFYGYLVTQIPA 138

Human   135 GFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRILQGLVEGVTYPACHGIWSKWA 198
            ||:..||..|::|||.|...:.||:|:|...:|... .|.|::|.||||:||.|||.||:|..||
 Worm   139 GFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWA 203

Human   199 PPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALH 263
            ||:|||:||||||.|||||||:.:||:..||.|..|::.||:||..|:.|.:.|..|::|.||.|
 Worm   204 PPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFH 268

Human   264 PSISEEERKYIEDAIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAY 328
            |:||:||:.:||||||..:. .:|..: |.||:...||.||:|||||||.|||||||||.:|..|
 Worm   269 PTISQEEKIFIEDAIGHVSN-THPTIR-SIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTY 331

Human   329 FEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCGGFGMEATLLL 393
            .:|..|.:|:..||::|:|||||..:|.:|||:||:|||.:|:|||.|||:.||||||.||..:|
 Worm   332 MKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKIFNCGGFGGEAAFML 396

Human   394 VVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA 458
            :|.|:.|...||..|:.|||.||||||||||||||||||||:||||.|||:|||:|:.||.:..|
 Worm   397 IVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEA 461

Human   459 MTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSE-------EKCGFVG---- 512
            .|.| ::..|..|||:|||:|:.||.||.|:||||.|.||||:|..|       .|.|..|
 Worm   462 FTAH-SKHGWTSVFLLASLIHFTGVTFYAVYASGELQEWAEPKEEEEWSNKELVNKTGINGTGYG 525

Human   513 -----HDQLAGSDDSEMEDEAEP-PGAPP 535
                 ..||....||..:.:|.| ||..|
 Worm   526 AAETTFTQLPAGVDSSYQAQAAPAPGTNP 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC17A7	NP_064705.1	MFS_SLC17A6_7_8_VGluT	66..490	CDD:340940	228/424 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..560		18/56 (32%)
eat-4	NP_499023.3	MFS_SLC17A6_7_8_VGluT	73..492	CDD:340940	228/424 (54%)