Protein Alignment CCNL1 and CycT

DIOPT Version :10

• Sequence 1: NP_064703.1
• Gene: CCNL1 / 57018
• HGNCID: 20569
• Length: 526
• Species: Homo sapiens
• Sequence 2: NP_524127.2
• Gene: CycT / 39961
• FlyBaseID: FBgn0025455
• Length: 1097
• Species: Drosophila melanogaster
• Alignment Length: 601
• Identity: 144/601 - (23%)
• Similarity: 237/601 - (39%)
• Gaps: 134/601 - (22%)

Human    11 AAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSL---------IPEERLSP 66
            ||.|:||::.||..|:||                     :.:|.:::|         ...::|:.
  Fly    11 AATASSSSSASAAASASG---------------------IPITANNNLPFEKDKIWYFSNDQLAN 54

Human    67 TPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMA 131
            :||.:.|:....|...|.:...|||..|..|::.|:.:.|..|..|||:...||.......:|.|
  Fly    55 SPSRRCGIKGDDELQYRQMTAYLIQEMGQRLQVSQLCINTAIVYMHRFYAFHSFTHFHRNSMASA 119

Human   132 CINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCV 196
            .:.||:|:||.||::..||         |......|...:|||.....:::..|..:|:.|||.|
  Fly   120 SLFLAAKVEEQPRKLEHVI---------RAANKCLPPTTEQNYAELAQELVFNENVLLQTLGFDV 175

Human   197 HVKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLR-TNVFVRFQPETIACACIYLAAR--ALQ 258
            .:.|||..:|...|:::..::  |.||::...::||. |::.::::|..:||.|||||.:  ..:
  Fly   176 AIDHPHTHVVRTCQLVKACKD--LAQTSYFLASNSLHLTSMCLQYRPTVVACFCIYLACKWSRWE 238

Human   259 IPLPTR-PHWFLLFGTTE--EEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKA--- 317
            ||..|. .|||.....|.  :.::::..|.:.:| .|.|  ..|:.::...|...|.|..:.
  Fly   239 IPQSTEGKHWFYYVDKTVSLDLLKQLTDEFIAIY-EKSP--ARLKSKLNSIKAIAQGASNRTANS 300

Human   318 --------------KGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKTVKKEPEDR 368
                          ||.:.:.|.....|.|.....:.......:..|:.|.|: :......|:.|
  Fly   301 KDKPKEDWKITEMMKGYHSNITTPPELLNGNDSRDRDRDRERERERERDPSSL-LPPPAMVPQQR 364

Human   369 QQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSH---------TPRRH---------YNNR 415
                       |:|....|:|..:....|.:.|.|.||         .|..|         ||||
  Fly   365 -----------RQDGGHQRSSSVSGVPGSSSSSSSSSHKMPNYPGGMPPDAHTDHKSKQPGYNNR 418

Human   416 ------RS------RSGTYSSRSRSRSRSHSESPRR------HHN--------------HGSPHL 448
                  ||      .||:.|.||.|.|.|.|:.|.|      :|.              ||| |.
  Fly   419 MPSSHQRSSSSGLGSSGSGSQRSSSSSSSSSQQPGRPSMPVDYHKSSRGMPPVGVGMPPHGS-HK 482

Human   449 KAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRDHSDAAKKHRHERGHHRDRRERSRSFERSHKSKH 513
            ....::..........|....:.|.|...|:|.|.:.|.:.:....:.:...::....|......
  Fly   483 MTSGSKPQQPQQQPVPHPSASNSSASGMSSKDKSQSNKMYPNAPPPYSNSAPQNPLMSRGGYPGA 547

Human   514 HGGSR----SGHGRHR 525
            ..||:    :|:|.||
  Fly   548 SNGSQPPPPAGYGGHR 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCNL1	NP_064703.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		10/24 (42%)
		CYCLIN_SF	40..195	CDD:477360	41/163 (25%)
		Cyclin-like 1	88..190		30/101 (30%)
		CYCLIN_SF	199..321	CDD:477360	36/144 (25%)
		Cyclin-like 2	203..287		24/89 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..526		57/262 (22%)
		RS	390..432		20/71 (28%)
CycT	NP_524127.2	CYCLIN_CCNT_rpt1	45..174	CDD:410241	39/137 (28%)
		CYCLIN_CCNT_rpt2	179..268	CDD:410242	26/90 (29%)