DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8A and coq8aa

DIOPT Version :9

Sequence 1:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_001002728.2	Gene:	coq8aa / 437001	ZFINID:	ZDB-GENE-040718-487	Length:	619	Species:	Danio rerio

Alignment Length:	636	Identity:	430/636 - (67%)
Similarity:	494/636 - (77%)	Gaps:	30/636 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     6 GDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAE 70
            ||.:::.:||.:|:||.:||....|..||     .:.:|.||.:.:|:.:.|:|          |
Zfish     3 GDMLLLMRGLARLSQAVIETQANSLRSGG-----VQTMQMTAEQAMGVAMQKIQ----------E 52

Human    71 NFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQAS 135
            ..|..:....||..  ..:..||:::....:||      ||.     ...:...||:|......:
Zfish    53 FTGSQQSVSDFSAD--MDSKYDFTASEQNFESA------AHG-----GLDSDSVFRDANTGAANT 104

Human   136 SPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEH 200
            ....:...:||...:|..|......|.:|||.|.|||:|||||||||:|| :..:|.|||.|||.
Zfish   105 YSQAQGKSKLFDGYKDPTSQFTGHTRSYHQDHSSVGGITAEDIEKAREAK-QNGSKPHKQMLSER 168

Human   201 ARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSG-KKAVLGSSPFLSEANAERIV 264
            ||||||||||:||||||||||||||.|||||||||||||||.:| |||||.||||||||||||||
Zfish   169 ARERKVPVTRLGRLANFGGLAVGLGIGALAEVAKKSLRSEDKNGNKKAVLDSSPFLSEANAERIV 233

Human   265 RTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLE 329
            |||||||||||||||||||||||||||.||||||||||||||||:|||.|.|:||||||||||||
Zfish   234 RTLCKVRGAALKLGQMLSIQDDAFINPQLAKIFERVRQSADFMPIKQMTKALSNDLGPNWRDKLE 298

Human   330 YFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHL 394
            .||||||||||||||||||||.|||||||||||||||||||||||||.||:|||.||||||||||
Zfish   299 MFEERPFAAASIGQVHLARMKDGREVAMKIQYPGVAQSINSDVNNLMTVLSMSNALPEGLFPEHL 363

Human   395 IDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGL 459
            |||:||||||||||.|||.|||||::|||.|||||||:::.||.|.||||||||.||||||||.|
Zfish   364 IDVMRRELALECDYIREAKCARKFKELLKDHPFFYVPDVISELSSQHVLTTELVPGFPLDQAEAL 428

Human   460 SQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQ 524
            :||::||||.|||.|||||||||.:|||||||||||||||.|:||||||||||.:|.||||:||:
Zfish   429 TQELKNEICKNILNLCLRELFEFRYMQTDPNWSNFFYDPQTHRVALLDFGATRGFDESFTDVYIE 493

Human   525 IIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHN 589
            ||:||||.:||.|..:||:||||||||.|.|.:||:||::||||||||:||||||.|||||:|||
Zfish   494 IIKAAADGNREGVLKQSIDMKFLTGYESKAMVNAHVDAVMILGEAFASEEPFDFGAQSTTERIHN 558

Human   590 LIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNY 640
            ||||||:.||:|||||||||||||||||||||:|.|:..||.|||.|||||
Zfish   559 LIPVMLKQRLIPPPEETYSLHRKMGGSFLICSRLNAKISCKDMFEAAYSNY 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		11/20 (55%)
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		2/2 (100%)
		ABC1_ADCK3	295..545	CDD:270872	204/249 (82%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		2/2 (100%)
coq8aa	NP_001002728.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..171		11/20 (55%)
		AarF	172..603	CDD:223733	359/430 (83%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	245..248		2/2 (100%)
		ABC1_ADCK3	264..514	CDD:270872	204/249 (82%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	306..309		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194344254
Domainoid	1	1.000	335	1.000	Domainoid score	I6299
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11345
Inparanoid	1	1.050	816	1.000	Inparanoid score	I3368
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53666
OrthoDB	1	1.010	-	-		D118642at7742
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		oto45481
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	LDO	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440