DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8A and abc1

DIOPT Version :9

Sequence 1:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_596237.1	Gene:	abc1 / 2540411	PomBaseID:	SPBC2D10.18	Length:	610	Species:	Schizosaccharomyces pombe

Alignment Length:	467	Identity:	211/467 - (45%)
Similarity:	283/467 - (60%)	Gaps:	16/467 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   177 DIEKARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSED 241
            |.|.:.:.....|||......|.     |||.::..||.::||||..|..||:.|..|:......
pombe   155 DFESSIEESYSTENKSPVILSSS-----KVPSSQWSRLWHYGGLATSLSVGAIGEKMKRMWGISK 214

Human   242 PSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADF 306
            ..|  |:|     |:|.|.|.:|..|.::||||||:|||||.||...|:|.:::|.||||..|..
pombe   215 DDG--ALL-----LNERNVEILVNKLTQMRGAALKMGQMLSFQDSKLIDPRVSQILERVRDGAHS 272

Human   307 MPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGR-EVAMKIQYPGVAQSINS 370
            ||.||:.:.:..:||.||......|:.:|.|||||||||.||:.... ||.:|:|||||..||:|
pombe   273 MPEKQLEQVMVKNLGKNWMTHYSEFDRKPMAAASIGQVHRARLASNHMEVVVKVQYPGVMSSIDS 337

Human   371 DVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVD 435
            |:|||..:|..|.:||:|||.|:.:...|:||..||||:||||.|.:|..|||....|.||.:..
pombe   338 DLNNLAYLLKASRILPKGLFLENSLAAARKELKWECDYEREAAFAERFGSLLKNDSDFKVPMVFR 402

Human   436 ELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQ 500
            |...|.|:|.|.:.|..|.: :..||..||.|.|.:...||||:.|:||||||||||||.|:.:.
pombe   403 EASGPSVITLEYLHGIALGK-QKYSQATRNHIGYLLTKQCLREISEYHFMQTDPNWSNFLYNGKT 466

Human   501 HKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILI 565
            .|:.||||||:.|||..|...|.:::.|||.|:||..:..|:|:.:|..:|...|.|||:::|..
pombe   467 KKIELLDFGASIEYDEKFIKKYCRLLLAAAHRNREKCKKLSVELGYLNNHESAQMIDAHINSIFT 531

Human   566 LGEAFASDEP--FDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFP 628
            |.|.||.|.|  :|||.|:.|.::...|||||..||.|||||||||||::.|.||:|:||.|:..
pombe   532 LAEPFAFDAPDVYDFGDQTITARVKQQIPVMLDLRLQPPPEETYSLHRRLSGHFLLCAKLGAKVR 596

Human   629 CKAMFEEAYSNY 640
            ||.:|.....:|
pombe   597 CKELFSGMLKHY 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		4/20 (20%)
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		1/2 (50%)
		ABC1_ADCK3	295..545	CDD:270872	120/250 (48%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		2/2 (100%)
abc1	NP_596237.1	AarF	170..610	CDD:223733	206/452 (46%)
abc1	NP_596237.1	ABC1_ADCK3	261..511	CDD:270872	120/250 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	193	1.000	Domainoid score	I819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11345
Inparanoid	1	1.050	376	1.000	Inparanoid score	I490
OMA	1	1.010	-	-		QHG53666
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm53613
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	O	PTHR43851
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.090