DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8A and coq-8

DIOPT Version :9

Sequence 1:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens
Sequence 2:	NP_498014.2	Gene:	coq-8 / 175647	WormBaseID:	WBGene00000767	Length:	755	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	240/480 - (50%)
Similarity:	324/480 - (67%)	Gaps:	25/480 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   179 EKARQAKARPENKQHKQTLSE--------HARERKVPVTRIGRLANFGGLAVGLGFGALAEVAK- 234
            :||:....|||..::.:...|        .:.|..||.|||||||.||.||.||..||.|||.:
Worm   271 QKAKPKVYRPELPKNFEVNLEMGNVHTLTRSNESSVPATRIGRLATFGQLAFGLLGGATAEVTRR 335

Human   235 -----KSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLA 294
                 |.|:.|.       :..:||||||||:|||.|||:||||||||||||||||.:.:.|.|.
Worm   336 TFGIGKRLQEEG-------IPKNPFLSEANADRIVATLCRVRGAALKLGQMLSIQDSSTVPPALL 393

Human   295 KIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKI 359
            :|||||||||||||:||:.:.:.:..|.:||:|.|:|:::|||.|||||||.|.:|.||.||:|:
Worm   394 QIFERVRQSADFMPIKQVHRQMKDAFGDDWREKFEHFDDKPFACASIGQVHKAVLKDGRNVAVKV 458

Human   360 QYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKG 424
            ||||||:.|:||::||::||::..:.|:|:|.:..:.|.||||..||||:|||...:|||:|:..
Worm   459 QYPGVAEGIDSDIDNLVSVLSVGGIFPKGMFLDAFVGVARRELKQECDYEREARAMKKFRELIAD 523

Human   425 HPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDP 489
            ....||||::|||.|..|||||||.|.|:|......|.:|:.|....:.|||:|:|.:.||||||
Worm   524 WQDVYVPEVIDELSSSRVLTTELVYGKPVDACVEEPQVVRDYIAGKFIELCLKEIFLWRFMQTDP 588

Human   490 NWSNFFYDPQ----QHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGY 550
            ||||||....    :.::.||||||:|.|.:.|.|:|:.||::|.|.|::.:...|.|:.|||||
Worm   589 NWSNFFLGKHPKTGEPRLVLLDFGASRAYGKKFVDIYMNIIKSAYDGDKKKIIEYSREIGFLTGY 653

Human   551 EVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGG 615
            |..||||||:::::|:||..||:.|::|..|..|.:|..||||||.|||..||||.||||||:.|
Worm   654 ETSVMEDAHVESVMIMGETLASNHPYNFANQDVTMRIQKLIPVMLEHRLTSPPEEIYSLHRKLSG 718

Human   616 SFLICSKLKARFPCKAMFEEAYSNY 640
            .:|:.:||||...|..:|.|.:.||
Worm   719 CYLLAAKLKATVSCGGLFHEIHENY 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		4/28 (14%)
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		2/2 (100%)
		ABC1_ADCK3	295..545	CDD:270872	126/253 (50%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		1/2 (50%)
coq-8	NP_498014.2	AarF	298..>707	CDD:223733	214/415 (52%)
coq-8	NP_498014.2	ABC1_ADCK3	394..648	CDD:270872	126/253 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I1726
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11345
Inparanoid	1	1.050	464	1.000	Inparanoid score	I936
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D128317at33208
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		otm16208
orthoMCL	1	0.900	-	-		OOG6_101512
Panther	1	1.100	-	-	O	PTHR43851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.000