Protein Alignment COQ8A and coq8a

DIOPT Version :10

• Sequence 1: NP_064632.2
• Gene: COQ8A / 56997
• HGNCID: 16812
• Length: 647
• Species: Homo sapiens
• Sequence 2: XP_031757718.1
• Gene: coq8a / 100379679
• XenbaseID: XB-GENE-946116
• Length: 644
• Species: Xenopus tropicalis
• Alignment Length: 653
• Identity: 445/653 - (68%)
• Similarity: 514/653 - (78%)
• Gaps: 24/653 - (3%)

Human     6 GDTIMVAKGLVKLTQAAVETHLQH-----LGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHE 65
            ||.:|:.:||.||::|.:|.....     ||:.|  |..||:.|....|:....:||:|...|.:
 Frog     4 GDALMLMRGLAKLSKAVLEVQAGQLRQPTLGVNG--IGFARSWQVAVEERFSAAMGKMQELGKQQ 66

Human    66 EYFAENFGGP--EGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREA 128
                ||..|.  |.|:.||.|.:..|..::|.:|:..|....|  .|.::....:|.:.|.....
 Frog    67 ----ENLAGQDMETEYSFSGPASEIAGMEYSPSSSQTQELHRS--EADAQNMDTSYRSQGQTDST 125

Human   129 GFPGQASSPLGRANGRLFANPRD---SFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPEN 190
            ..|..:   ..|.||.||.:.||   .|:|.| |:|.||||.|.|.|||||||:|||:||..|.|
 Frog   126 FHPDPS---FERDNGALFGDVRDRAGPFAAYG-QKRAFHQDHSSVSGLTAEDIDKAREAKNNPAN 186

Human   191 KQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSL--RSEDPSGKKAVLGSSP 253
            |.|||.||:.|||||||||||||||||||||||||.|||||||||||  :.::.||||:|:.|||
 Frog   187 KPHKQMLSDRARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKSLSPKPDNGSGKKSVMDSSP 251

Human   254 FLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNN 318
            |||||||||||||||||||||||||||||||||:||||.|.|:||||||||||||:|||||||||
 Frog   252 FLSEANAERIVRTLCKVRGAALKLGQMLSIQDDSFINPQLQKVFERVRQSADFMPIKQMMKTLNN 316

Human   319 DLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSN 383
            |||||||||||.||||||||||||||||||:|.|||||||||||||||||:|||||||.||||||
 Frog   317 DLGPNWRDKLESFEERPFAAASIGQVHLARLKDGREVAMKIQYPGVAQSIHSDVNNLMTVLNMSN 381

Human   384 MLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELV 448
            .|||||||||||:||.|||||||||:|||.|.:||::||:.|||||||.::|||||.||||||||
 Frog   382 ALPEGLFPEHLIEVLSRELALECDYKREADCCKKFKELLQDHPFFYVPGVIDELCSGHVLTTELV 446

Human   449 SGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATRE 513
            ||||||||||||||.|||||||||||||||||||.|||||||||||||||||:|||||||||||.
 Frog   447 SGFPLDQAEGLSQETRNEICYNILVLCLRELFEFRFMQTDPNWSNFFYDPQQNKVALLDFGATRG 511

Human   514 YDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDF 578
            :|..|||:||::||||||:|||.:..||:|||||:|||.|.||.|||:|:||||||||:|.||||
 Frog   512 FDEEFTDMYIEVIRAAADQDREKLLRKSVEMKFLSGYESKAMEQAHLEAVLILGEAFAADSPFDF 576

Human   579 GTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKR 643
            |:|||||:||.|:|:||:|||:|||||||||||||.||||||||||:...||.||||||.||.|.
 Frog   577 GSQSTTERIHRLVPIMLKHRLIPPPEETYSLHRKMAGSFLICSKLKSAISCKDMFEEAYGNYWKG 641

Human   644 QAQ 646
            :::
 Frog   642 KSK 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..117		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..203		12/20 (60%)
		KxGQ motif. /evidence=ECO:0000269|PubMed:25498144	276..279		2/2 (100%)
		ABC1_ADCK3	295..545	CDD:270872	211/249 (85%)
		AAAS motif. /evidence=ECO:0000269|PubMed:25498144	337..340		2/2 (100%)
coq8a	XP_031757718.1	ABC1_ADCK3	293..543	CDD:270872	211/249 (85%)