DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment COQ8A and coq8a

DIOPT Version :9

Sequence 1:	NP_064632.2	Gene:	COQ8A / 56997	HGNCID:	16812	Length:	647	Species:	Homo sapiens
Sequence 2:	XP_031757718.1	Gene:	coq8a / 100379679	XenbaseID:	XB-GENE-946116	Length:	644	Species:	Xenopus tropicalis

Alignment Length:	653	Identity:	445/653 - (68%)
Similarity:	514/653 - (78%)	Gaps:	24/653 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     6 GDTIMVAKGLVKLTQAAVETHLQH-----LGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHE 65
            ||.:|:.:||.||::|.:|.....     ||:.|  |..||:.|....|:....:||:|...|.:
Frog     4 GDALMLMRGLAKLSKAVLEVQAGQLRQPTLGVNG--IGFARSWQVAVEERFSAAMGKMQELGKQQ 66

Human    66 EYFAENFGGP--EGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREA 128
                ||..|.  |.|:.||.|.:..|..::|.:|:..|....|  .|.::....:|.:.|.....
Frog    67 ----ENLAGQDMETEYSFSGPASEIAGMEYSPSSSQTQELHRS--EADAQNMDTSYRSQGQTDST 125

Human   129 GFPGQASSPLGRANGRLFANPRD---SFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPEN 190
            ..|..:   ..|.||.||.:.||   .|:|.| |:|.||||.|.|.|||||||:|||:||..|.|
Frog   126 FHPDPS---FERDNGALFGDVRDRAGPFAAYG-QKRAFHQDHSSVSGLTAEDIDKAREAKNNPAN 186

Human   191 KQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSL--RSEDPSGKKAVLGSSP 253
            |.|||.||:.|||||||||||||||||||||||||.|||||||||||  :.::.||||:|:.|||
Frog   187 KPHKQMLSDRARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKSLSPKPDNGSGKKSVMDSSP 251

Human   254 FLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNN 318
            |||||||||||||||||||||||||||||||||:||||.|.|:||||||||||||:|||||||||
Frog   252 FLSEANAERIVRTLCKVRGAALKLGQMLSIQDDSFINPQLQKVFERVRQSADFMPIKQMMKTLNN 316

Human   319 DLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSN 383
            |||||||||||.||||||||||||||||||:|.|||||||||||||||||:|||||||.||||||
Frog   317 DLGPNWRDKLESFEERPFAAASIGQVHLARLKDGREVAMKIQYPGVAQSIHSDVNNLMTVLNMSN 381

Human   384 MLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELV 448
            .|||||||||||:||.|||||||||:|||.|.:||::||:.|||||||.::|||||.||||||||
Frog   382 ALPEGLFPEHLIEVLSRELALECDYKREADCCKKFKELLQDHPFFYVPGVIDELCSGHVLTTELV 446

Human   449 SGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATRE 513
            ||||||||||||||.|||||||||||||||||||.|||||||||||||||||:|||||||||||.
Frog   447 SGFPLDQAEGLSQETRNEICYNILVLCLRELFEFRFMQTDPNWSNFFYDPQQNKVALLDFGATRG 511

Human   514 YDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDF 578
            :|..|||:||::||||||:|||.:..||:|||||:|||.|.||.|||:|:||||||||:|.||||
Frog   512 FDEEFTDMYIEVIRAAADQDREKLLRKSVEMKFLSGYESKAMEQAHLEAVLILGEAFAADSPFDF 576

Human   579 GTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKR 643
            |:|||||:||.|:|:||:|||:|||||||||||||.||||||||||:...||.||||||.||.|.
Frog   577 GSQSTTERIHRLVPIMLKHRLIPPPEETYSLHRKMAGSFLICSKLKSAISCKDMFEEAYGNYWKG 641

Human   644 QAQ 646
            :::
Frog   642 KSK 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COQ8A	NP_064632.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..117		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		12/20 (60%)
		KxGQ motif. /evidence=ECO:0000269\|PubMed:25498144	276..279		2/2 (100%)
		ABC1_ADCK3	295..545	CDD:270872	211/249 (85%)
		AAAS motif. /evidence=ECO:0000269\|PubMed:25498144	337..340		2/2 (100%)
coq8a	XP_031757718.1	ABC1_ADCK3	293..543	CDD:270872	211/249 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I7109
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11345
Inparanoid	1	1.050	849	1.000	Inparanoid score	I4051
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118642at7742
OrthoFinder	1	1.000	-	-		FOG0001764
OrthoInspector	1	1.000	-	-		oto150505
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9
SonicParanoid	1	1.000	-	-		X1120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090