Protein Alignment SHD and shf

DIOPT Version :10

• Sequence 1: NP_064594.3
• Gene: SHD / 56961
• HGNCID: 30633
• Length: 340
• Species: Homo sapiens
• Sequence 2: XP_012825634.2
• Gene: shf / 100216125
• XenbaseID: XB-GENE-492850
• Length: 554
• Species: Xenopus tropicalis
• Alignment Length: 510
• Identity: 186/510 - (36%)
• Similarity: 245/510 - (48%)
• Gaps: 171/510 - (33%)

Human     1 MAKWLRDYLSF-GGRRPPPQPPTPDYT------------------------------ESDILRAY 34
            ||||::::|.| ..:.|||.||.|||.                              :.|||.||
 Frog    44 MAKWIKEHLGFKSSKPPPPAPPKPDYRLCQAGGASTHHHHHHHLHSAVPQFPVTPAGQPDILAAY 108

Human    35 RAQKNLDFEDPY-----EDAESRLEPD---PAGPGDS--KNPG------DAKYGSPKHRLIKVEA 83
            :.||..||||||     ..|.::|...   |:.|..|  ::|.      |.||.|||||||||:.
 Frog   109 KLQKERDFEDPYTTCGAPGASAQLNSSTVPPSAPTSSSAQSPSSPSHSPDVKYVSPKHRLIKVDT 173

Human    84 ADM-------ARAKALLGGPG-------------------------EELEAD-----TEYLDPFD 111
            .:.       .......|.||                         ||.:.|     .:|.||||
 Frog   174 GEKGSCSPTGGNTAGSSGSPGQAFTSPSVPSPGVRSPPATAVAPQLEESKQDKVAIVEDYADPFD 238

Human   112 AQ--------PHPAPPDDGYMEPYDAQWVMSELPGRG--------VQLYDTPYE--EQDPETADG 158
            |:        |.....:|||||||:||.:|:|:..||        :.|||||||  |...::...
 Frog   239 AKQVPGSQNAPEKVTENDGYMEPYEAQKMMAEIRRRGSKELPCTPLHLYDTPYEPSENGLDSEGE 303

Human   159 PPSGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAV------------------------- 198
            ..:.|:||:||:||:||||.:||||||||||:.||:||||
 Frog   304 KSTSQRPRESRLPQDDERPPEEYDQPWEWKKERISKAFAVEIKVIKDLPWPPPVGQLNSRTASAE 368

Human   199 ----------------------------QFDSPE---------------WERTPGSAKELRRPP- 219
                                        ||||.:               ...:.|:.|.::.|.
 Frog   369 NDLSTSFSQQTPTSPHFQRQASLEDSNAQFDSADKTGMAAAKEDKPRHMHRHSAGNLKAIKHPSV 433

Human   220 PRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGF 284
            .......||:||:||||.|.|:||.::||||||||.||||.|||||.||||..|.||||:|.|||
 Frog   434 EHCISVGERIDPSLPLESQFWYHGAISRADAESLLRLCKEASYLVRNSETNKIDFSLSLKSIQGF 498

Human   285 LHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYPVVTQT 339
            :|:|.:||:||:.|||.:|.||.||||::.||:|:.||::||||::|||||..:|
 Frog   499 MHMKLSRTKENKYVLGHNSPPFNSVPEIIHHYASQKLPIKGAEHMSLLYPVAVRT 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SHD	NP_064594.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		39/122 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..186		50/139 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..230		10/100 (10%)
		SH2_SHD	238..335	CDD:198253	62/96 (65%)
shf	XP_012825634.2	SH2_SHF	452..549	CDD:198255	62/96 (65%)