DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1ab and para

DIOPT Version :9

Sequence 1:XP_021335317.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2336 Species:Danio rerio
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2371 Identity:525/2371 - (22%)
Similarity:903/2371 - (38%) Gaps:760/2371 - (32%)


- Green bases have known domain annotations that are detailed below.


Zfish    58 PIPVR---------------------QNCLTV-----NRSLFLFSED---------NIVRKYAKK 87
            |||||                     .|.||.     .:.:|.||..         |.:|:.|..
  Fly    84 PIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIY 148

Zfish    88 ITEWPPFEWMILTTIIANCIVLALEQHLPVGDKTPLSERLEETEPYFIAIFCFESGIKILALGFA 152
            |...|.|...|:|||:.|||::.:          |.:..:|.||..|..|:.|||.:|::|.||.
  Fly   149 ILVHPLFSLFIITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFI 203

Zfish   153 FHKGSYLRNGWNVMDFVVVLTGILSSVGSEL-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKA 216
            ....:|||:.||.:||||:....: ::|.:| :|..||..||||.||.|:.:|.|:.::.:::::
  Fly   204 LCPFTYLRDAWNWLDFVVIALAYV-TMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIES 267

Zfish   217 MIPLLQIGVLLFVAILMFAIIGLEFYMGKFHTTC---------FNTITGEMYDERP--------- 263
            :..|..:.:|...::.:||::||:.|||.....|         :..:|.|.:|...         
  Fly   268 VKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSE 332

Zfish   264 --------C----GARTCDANNTQCQGYWLGPNYGITQFDNVLFAVLTVFQCITMEGWTDMLYYS 316
                    |    ||..||.:....||:...||||.|.||:..:|.|:.|:.:|.:.|.|:....
  Fly   333 DEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLV 397

Zfish   317 NDALGSAWNWMYYVPLIIIGSFFMLNLVLGVLSGEF------AKERERVE----NRSEFLKLKRQ 371
            ..|.| .|:.::::.:|.:|||:::||:|.:::..:      |:|.|..|    ..:|.....:.
  Fly   398 LRAAG-PWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKA 461

Zfish   372 QQIERELNGYLE----------------------WICKAEEVIL-AEDDNDTGSRRRPTLKKNKA 413
            .::|...|...:                      :.|.:.|:.: .|..||..::.:.:::..:.
  Fly   462 AKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEV 526

Zfish   414 D-------LLNPQEGVDHMGDSV-----------GSPF--ARGSMS--------GKG-------- 442
            :       ...|.....|....|           ||||  .|||.|        |:|        
  Fly   527 ESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSD 591

Zfish   443 -------------------DE----TPFSK----------------------------------- 449
                               |:    ||.|:                                   
  Fly   592 RKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGD 656

Zfish   450 --------------KERRLR--------------------------------------------- 455
                          ||.:||                                             
  Fly   657 LLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKH 721

Zfish   456 ----FLIRKMVKTQ-------------------------------AFYWTV-------------- 471
                |:  :.|:||                               .:|:..              
  Fly   722 HDNPFI--EPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKA 784

Zfish   472 --------------------------ISL--------------VALNTLCVAVVHYDQPELLSDF 496
                                      :||              :.:||:.:|:.|:|..:.:...
  Fly   785 LEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERV 849

Zfish   497 LYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCAVIVGSIFEVVWAMVKPGTSFGISVLR 561
            |....:.|...|..|..:|:..:..:.||...:|.||..::..|:.|:....|:     |:||||
  Fly   850 LKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLR 909

Zfish   562 ALRLLRIFKVTKYWASLRNLVVSLL-NSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN-----F 620
            :.||||:||:.|.|.:| ||::|:: .:|.::.:|.|:|.:.|.:||::||||||..::     |
  Fly   910 SFRLLRVFKLAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRF 973

Zfish   621 ELG-TPPTNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDKGMIFSV-FFIVLTLFGNYTL 683
            ..| .|..||..|..:.|.||::|.|| |...|:|.:.      .|.:..: ||:...:.||..:
  Fly   974 PDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCMY------VGDVSCIPFFLATVVIGNLVV 1031

Zfish   684 LNVFLAIAVDNLA----NAQELTKDEQEEEEATTQ--KMALQKAKEVAEVSPLSAANLSIAAKEQ 742
            ||:|||:.:.|..    :|.....|..:..||..:  :......:.:|:...|....|:....:|
  Fly  1032 LNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQ 1096

Zfish   743 QKNSKGSKSVWEQRTSEIRRQNLMTSREALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQEN 807
            ....:.::..|           :.:..:.:...:.||               |.|..|.:...|.
  Fly  1097 PSGERTNQISW-----------IWSEGKGVCRCISAE---------------HGDNELELGHDEI 1135

Zfish   808 RNNNTNKPRPDDPNPQERSEEHPSRSHHHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEG 872
            ..:...|                                   ...::...|......|.|..:.|
  Fly  1136 LADGLIK-----------------------------------KGIKEQTQLEVAIGDGMEFTIHG 1165

Zfish   873 AGEHRRPRHHQH--RRRDED-------GGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANH 928
            ..::.:|:..::  ...|:|       |..:.|..:|...:|   ..:..:|:|||         
  Fly  1166 DMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKG---SAETMEGEEKR--------- 1218

Zfish   929 GDGDGRRERSRLHRNKKEGSLSTARPIQPGLPHTESQYSEDLDNLRNSSKMAIHDPDPDLYDPYY 993
               |..:|...|.....|.......|:                    ...:.||..|.|:.|.| 
  Fly  1219 ---DASKEDLGLDEELDEEGECEEGPL--------------------DGDIIIHAHDEDILDEY- 1259

Zfish   994 DPEQANNLLNLRGPDLHDSSLILTDSSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKE 1058
             |...       .||.:...                   :|.|                      
  Fly  1260 -PADC-------CPDSYYKK-------------------FPIL---------------------- 1275

Zfish  1059 EEEDDGGDEE-------GHKRIPPFSSCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIAL 1116
                 .||::       |:.|:..|.                 ::..:|||..::::|.|||:||
  Fly  1276 -----AGDDDSPFWQGWGNLRLKTFQ-----------------LIENKYFETAVITMILMSSLAL 1318

Zfish  1117 AAED------PVSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLDFVV 1175
            |.||      |:.||     :|.|.|.:||.:|..|||||.:.||..:    ||.:.|.:||||:
  Fly  1319 ALEDVHLPQRPILQD-----ILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWLDFVI 1374

Zfish  1176 VSGALVAFAFTSFSGGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNIL 1240
            |..:|:.|. .|..|..|    |...|::|.||.||||:.:.|:..::.|.:.:|.::.::.|:|
  Fly  1375 VMVSLINFV-ASLVGAGG----IQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVL 1434

Zfish  1241 IVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFARDCRGEYLVYE---RDNEVKSQKREWKKYDFH 1302
            :|.::|..|||::.||||.|::|.|        .|..|..|.:|   ..|..:|:...|.....:
  Fly  1435 LVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIPNRNACESENYTWVNSAMN 1491

Zfish  1303 YDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIF---YVVYFVVF-PFFFV 1363
            :|:|..|.|.||.|:|.:||..::..::||...::.|.    .|.:|:   |.|:|::| .||.:
  Fly  1492 FDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPI----RETNIYMYLYFVFFIIFGSFFTL 1552

Zfish  1364 NIFVALIIITFQEQGDK--------MMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQYRMW 1420
            |:|:.:||..|.||..|        |.||   :|.....:....:.||| :.:|:.:...|..::
  Fly  1553 NLFIGVIIDNFNEQKKKAGGSLEMFMTED---QKKYYNAMKKMGSKKPL-KAIPRPRWRPQAIVF 1613

Zfish  1421 QFVVSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVR-N 1484
            :.|....|:..||..|.||...:.:....|||.|:.||..||.:|...|..|.:|||  |.:| :
  Fly  1614 EIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKI--FALRYH 1676

Zfish  1485 FFRDAWNIFDFVSVIGSITDILVTELVNN-FINLSFLRLFRAA---RLIKLLRQGETIRILLWTF 1545
            :|.:.||:||.|.||.||..:::::::.. |::.:.||:.|.|   |:::|::..:.||.||:..
  Fly  1677 YFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFAL 1741

Zfish  1546 VQSFKALPYVCLLIAILFFIYAIIGMQLFGNLALDDEGAINEHNNFRTFFMALMLLFRSATGEAW 1610
            ..|..||..:|||:.::.||:||.||..|  :.:.::..||:..||:||..:::|||:.:|...|
  Fly  1742 AMSLPALFNICLLLFLVMFIFAIFGMSFF--MHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGW 1804

Zfish  1611 HDIMLSCLGGMPCEPEE----VGSECGS-NVAYAYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1670
            ..::.:.:....|:|.:    ....||| .|...:.:|::.:...:::|:::|||::|:...|.|
  Fly  1805 DGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATED 1869

Zfish  1671 -SSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLP 1734
             ...|.....|.|..||.::||.....|.|..:...|.|::|||.:.|  |::.   :::.||:|
  Fly  1870 VQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY---KIISMDIP 1929

Zfish  1735 VADDNTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSA 1799
            :...:.::           .:||           :|| |.|:..|...|..::..:         
  Fly  1930 ICRGDLMY-----------CVDI-----------LDA-LTKDFFARKGNPIEETGE--------- 1962

Zfish  1800 TDLTVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPELPQEP 1864
                :|:|.|                                   .|:.||           .||
  Fly  1963 ----IGEIAA-----------------------------------RPDTEG-----------YEP 1977

Zfish  1865 VNSLPPEVGMNESQSWVTSRAQEMCQKSVPENWNPDRP--------YPDDHHDSRHNPQTVEMRE 1921
            |:          |..|  .:.:|.|.:.:...|...:.        .||..|....:|...:   
  Fly  1978 VS----------STLW--RQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGD--- 2027

Zfish  1922 FGPVGDGYSDTEPYHPMEGHGRTISMPRLSADNQRRRHRPRGSNLSTITDTSPMRRSTSSLVHGR 1986
              |..|..:|.:.  |..|.|........:||.........|.:.:.....:....:..:...|.
  Fly  2028 --PAPDEATDGDA--PAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGS 2088

Zfish  1987 SGRG---------VRLDDYSLERVVSEEGHR 2008
            .|.|         |..|.:     |::.||:
  Fly  2089 PGAGSAGRQTAVLVESDGF-----VTKNGHK 2114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1abXP_021335317.1 Ion_trans 91..360 CDD:306908 91/305 (30%)
Ion_trans 465..703 CDD:306908 79/334 (24%)
Ion_trans 1099..1335 CDD:306908 86/244 (35%)
Ion_trans 1425..1672 CDD:306908 81/257 (32%)
GPHH 1673..1743 CDD:318993 19/69 (28%)
Ca_chan_IQ 1745..1820 CDD:312334 11/74 (15%)
Herpes_ICP4_C 1841..>2243 CDD:332854 32/185 (17%)
PAT1 <2144..2300 CDD:330585
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 82/282 (29%)
Na_trans_cytopl 515..648 CDD:288761 17/132 (13%)
Ion_trans 835..1028 CDD:278921 64/205 (31%)
Na_trans_assoc 1054..1296 CDD:284034 50/392 (13%)
Ion_trans 1318..1571 CDD:278921 95/278 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 75/238 (32%)
GPHH 1880..1930 CDD:293510 17/54 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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