DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MRPS22 and mrps-22

DIOPT Version :9

Sequence 1:	NP_064576.1	Gene:	MRPS22 / 56945	HGNCID:	14508	Length:	360	Species:	Homo sapiens
Sequence 2:	NP_496281.1	Gene:	mrps-22 / 174632	WormBaseID:	WBGene00007564	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	292	Identity:	99/292 - (33%)
Similarity:	165/292 - (56%)	Gaps:	19/292 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    56 EAAESGSPE--TKKPTFMDEEVQSILTKMTGLNLQ-KTFKP---AIQELKPPTYKLMTQAQLEEA 114
            :|:.|.:|:  ..:..|:::|||.:||.:|.::|: |.|:|   :||:..  .:.|||:.:||:.
Worm    26 KASNSKTPDDINVEKLFVEKEVQKLLTDLTEIDLEHKVFRPRRTSIQQRS--HFALMTEERLEKT 88

Human   115 TRQAVEAAKVRLKMPPVLEERVPINDVLAEDKILEGTETTKYVFTDISYSIPHRERFIVVREPSG 179
            ..:..|.|:..|:..||.|.|.....:||:|..|:..:|:|:|||||::....::|.:|||||.|
Worm    89 RERMREEARRFLQFVPVKEPREESVQILAKDLELKDFDTSKFVFTDITFDATDQDRTVVVREPDG 153

Human   180 TLRKASWEERDRMIQVYFPKEGRKILTPIIFKEENLRTMYSQDRHVDVLNLCFAQFEPDSTEYIK 244
            |||.|:.||.|||.:.|:.|..|.:..|.:|.:.||:....::.|..||:.....:|||...|::
Worm   154 TLRTANPEEHDRMNRTYYQKPNRSVNPPPLFSDPNLQNALDKNDHEFVLDWACWFYEPDDPAYVR 218

Human   245 VHHKTYEDIDKRGKYDLLRSTRYFGGMVWYFVNNKKIDGLL--IDQIQRDLIDDATNLVQLYHVL 307
            :....::.|::.||:.::.|||:||...:|...|..|..||  ...:.|  :.|..|||:|...:
Worm   219 LSQLVFDRINESGKFHVVTSTRHFGPFTFYLALNDNIQKLLNYFGGLGR--LSDCANLVRLQKAV 281

Human   308 HPDGQ--SAQGAKDQAAEGINLIKVFAKTEAQ 337
            .||.:  .|||..|:     .::|.|||..|:
Worm   282 RPDWRVTIAQGDSDE-----KIVKDFAKQNAR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MRPS22	NP_064576.1	MRP-S22	70..309	CDD:402036	85/244 (35%)
mrps-22	NP_496281.1	MRP-S22	40..282	CDD:287247	85/245 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161451871
Domainoid	1	1.000	146	1.000	Domainoid score	I3087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57030
Inparanoid	1	1.050	155	1.000	Inparanoid score	I3325
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363634at33208
OrthoFinder	1	1.000	-	-		FOG0007406
OrthoInspector	1	1.000	-	-		oto23273
orthoMCL	1	0.900	-	-		OOG6_107905
Panther	1	1.100	-	-	LDO	PTHR13071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4394
SonicParanoid	1	1.000	-	-		X5531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930