DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment npr3 and Gyc76C

DIOPT Version :9

Sequence 1:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	95/508 - (18%)
Similarity:	179/508 - (35%)	Gaps:	178/508 - (35%)

- Green bases have known domain annotations that are detailed below.

Zfish    89 RQKDERPDLVL--------------------GPVCEYAASSVTRVASHWNIPVIS-------AGA 126
            |..|.:.|.||                    ||....|..|.:|     |||:||       |.|
  Fly    72 RWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQSR-----NIPMISYKCAEYRASA 131

Zfish   127 LATGFNSKTPEYSHLTRIAPTYLKMAETFQAIFGHFGWRTAYLIYDDDKDERNCYFTMEGVFTVL 191
            :.|...::.|:    |::..:.|       |:..::.|....::|:|         ....|..:|
  Fly   132 IPTFARTEPPD----TQVVKSLL-------ALLRYYAWNKFSILYED---------VWSPVADLL 176

Zfish   192 SEYHISTDFAVLNSNEERVDPDGIITSVYGSEVVIMCSKA----DIVRDLMLAAHRRKL-----T 247
            .:.....:..: |..:..:|     ..|...|.::.|.::    .:|::.|   :|.::     .
  Fly   177 KDQATKRNMTI-NHKQSFID-----NRVKCCEQMLDCCRSGYWYQLVQNTM---NRTRIYVFLGA 232

Zfish   248 SDSHIFFNIELFNSSSYGDGSW------------RRRDKY----------------DDEARAAYS 284
            ::|.:.|...:..:..:..|.:            |..:||                ::..:.|.|
  Fly   233 ANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARS 297

Zfish   285 FLNTVTLLRSTKPEFE---------------DFSIEMKKSLQQSNIPICEDCSAVNMFMEGFHDA 334
            .|    ::.||.|..:               .|::|:.:...:||.     ...::::....:|:
  Fly   298 LL----VVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNF-----SKFISIYAAYLYDS 353

Zfish   335 LLLYAIA----LREVKSKGLT-------KKNGLEITHS-MWNRTFEGIAG-QVSLDANGDRNGDF 386
            :.|||.|    ||| :::.||       ..||..:..: :.|||:..|.| ::.:|..||..|:|
  Fly   354 VKLYAWAVDKMLRE-ETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNF 417

Zfish   387 SVV--------RMTDPESGKHETVMNYFG----------TNGSFQILPGFKREWFSLRTIPPPKP 433
            ||:        ...:.....|...:.||.          .|||.        :|.|    ...||
  Fly   418 SVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSI--------DWPS----GGEKP 470

Zfish   434 LDPSSGGLG-----------VSAVTGIIVGGILGTALLLAFYFFRKNYRITIE 475
            .|....|..           .|.|..:::|.:|..:.::....:|| ::|.:|
  Fly   471 ADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRK-WKIELE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	81/436 (19%)
		ANF_receptor	46..389	CDD:279440	74/391 (19%)
		TM_EphA1	436..468	CDD:214014	5/42 (12%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	76/416 (18%)
		ANF_receptor	48..412	CDD:279440	69/383 (18%)
		PK_GC-A_B	543..827	CDD:270944
		HNOBA	<835..881	CDD:285003
		CYCc	860..1052	CDD:214485
		Guanylate_cyc	887..1074	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810