Protein Alignment NMUR2 and PK1-R

DIOPT Version :10

• Sequence 1: NP_064552.3
• Gene: NMUR2 / 56923
• HGNCID: 16454
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_001014620.1
• Gene: PK1-R / 41713
• FlyBaseID: FBgn0038201
• Length: 430
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 121/365 - (33%)
• Similarity: 194/365 - (53%)
• Gaps: 73/365 - (20%)

Human    38 GPRRS--HFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMP 100
            ||.|.  ...:||:|||..||:.||:||:..|:||.::::|.|.|||||||||:||.|:||.|:|
  Fly    11 GPPRDPLAIVIPVTVVYSLIFITGVVGNISTCIVIKKNRSMHTATNYYLFSLAISDFLLLLSGVP 75

Human   101 LEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALR 165
            .||..:|..||::||...|..:..|.||...|::|:||..:||||:||.|||..:..|...||:|
  Fly    76 QEVSYIWSKYPYVFGEYICIGRGLLAETSANATVLTITAFTVERYIAICHPFLGQAMSKLSRAIR 140

Human   166 ILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMT 230
            |:.:||..:::.::|..:..||: ||       .|...|.:::.:..::|  |:::|:|:|.||:
  Fly   141 IIVLVWIMAIVTAIPQAAQFGIE-HY-------SGVEQCGIVRVIVKHSF--QLSTFIFFLAPMS 195

Human   231 VISVLYYLMALRLKKDKSLEADEGNANIQRPCR-------------------------------- 263
            :|.|||.|:.:.|.:...:   ||.|::.|..:
  Fly   196 IILVLYLLIGVHLYRSTLV---EGPASVARRQQLKSVPSDTILYRYGGSGTAMSFNGGGSGAGTA 257

Human   264 ----------------------KSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESL----A 302
                                  :.|.:||..:|:.|.:||||||..||...:.......|    .
  Fly   258 GLMGGSGAQLSSVRGRLNHYGTRRVLRMLVAVVVCFFLCWAPFHAQRLIAIYAPARGAKLRDQHE 322

Human   303 AVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI 342
            .|:.::..||||.:|||:.:||::||::|.:|:.||:.|:
  Fly   323 FVYTVMTYVSGVLYYLSTCINPLLYNIMSHKFREAFKAVL 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tmA_NMU-R2	46..338	CDD:320479	115/349 (33%)
		TM helix 1	46..73	CDD:320479	14/26 (54%)
		TM helix 2	80..106	CDD:320479	18/25 (72%)
		TM helix 3	119..149	CDD:320479	13/29 (45%)
		TM helix 4	161..183	CDD:320479	7/21 (33%)
		TM helix 5	213..242	CDD:320479	12/28 (43%)
		TM helix 6	261..291	CDD:320479	13/83 (16%)
		TM helix 7	306..331	CDD:320479	11/24 (46%)
		NmU-R2_C_term	331..397	CDD:466027	5/12 (42%)
PK1-R	NP_001014620.1	7tmA_capaR	21..358	CDD:320262	115/349 (33%)
		TM helix 1	21..48	CDD:320262	14/26 (54%)
		TM helix 2	55..81	CDD:320262	18/25 (72%)
		TM helix 3	94..124	CDD:320262	13/29 (45%)
		TM helix 4	136..158	CDD:320262	7/21 (33%)
		TM helix 5	178..207	CDD:320262	12/30 (40%)
		TM helix 6	277..307	CDD:320262	13/29 (45%)
		TM helix 7	326..351	CDD:320262	11/24 (46%)