Protein Alignment NMUR2 and PK2-R1

DIOPT Version :10

• Sequence 1: NP_064552.3
• Gene: NMUR2 / 56923
• HGNCID: 16454
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_731790.1
• Gene: PK2-R1 / 41639
• FlyBaseID: FBgn0038140
• Length: 660
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 133/443 - (30%)
• Similarity: 212/443 - (47%)
• Gaps: 78/443 - (17%)

Human    20 DPFQKH----LNSTEEYLAFLCG--------------PRRSHFFL--PVSVVYVPIFVVGVIGNV 64
            |.|..|    ||.|.|.|:.|.|              |......|  .::|.|..|||.||:||:
  Fly    62 DKFLTHVAHLLNITTENLSNLLGSTNGTNASTMAADSPVDESLTLRTALTVCYALIFVAGVLGNL 126

Human    65 LVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYP--FLFGPVGCYFKTALFE 127
            :.|:||.::..|.|.||:|||:||||||::|:.|:|.|:|.:|  ||  :.|....|...:.|.|
  Fly   127 ITCIVISRNNFMHTATNFYLFNLAVSDLILLVSGIPQELYNLW--YPDMYPFTDAMCIMGSVLSE 189

Human   128 TVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFH-- 190
            ....|::|:||..:||||:||.||||....|...||::.:..:|..:.|.:||......:.:.
  Fly   190 MAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAIKFIFAIWLAAFLLALPQAMQFSVVYQNE 254

Human   191 -YFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDK---SLEA 251
             |           :||:...  .|..:..|:.|:|:..|||.|.|||.|:.::||:.:   ||..
  Fly   255 GY-----------SCTMEND--FYAHVFAVSGFIFFGGPMTAICVLYVLIGVKLKRSRLLQSLPR 306

Human   252 DEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSF------VEEWSESLAAVFNLVHV 310
            ...:||.....:..|.:||..:.:.|.:||||||..||...:      :....::....|.::..
  Fly   307 RTFDANRGLNAQGRVIRMLVAVAVAFFLCWAPFHAQRLMAVYGLNLINIGISRDAFNDYFRILDY 371

Human   311 VSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI--------SSFHKQ-WHSQHD----------PQ 356
            .|||.::||:.:||::||::|.:|:.||:..:        :..|:| .|.||:          .:
  Fly   372 TSGVLYFLSTCINPLLYNIMSHKFREAFKITLTRQFGLARNHHHQQSQHHQHNYSALLRQNGSMR 436

Human   357 LPPAQRNIFLTECHFVELTEDIGP----QFPCQSSMHNSHLPAALSSEQMSRT 405
            |.||..::      .....|..|.    ||.|:.:.|...|..::.:...:.|
  Fly   437 LQPASCSV------NNNALEPYGSYRVVQFRCRDANHQLSLQDSIRTTTTTTT 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tmA_NMU-R2	46..338	CDD:320479	104/307 (34%)
		TM helix 1	46..73	CDD:320479	13/28 (46%)
		TM helix 2	80..106	CDD:320479	16/25 (64%)
		TM helix 3	119..149	CDD:320479	12/29 (41%)
		TM helix 4	161..183	CDD:320479	6/21 (29%)
		TM helix 5	213..242	CDD:320479	12/28 (43%)
		TM helix 6	261..291	CDD:320479	12/29 (41%)
		TM helix 7	306..331	CDD:320479	9/24 (38%)
		NmU-R2_C_term	331..397	CDD:466027	19/88 (22%)
PK2-R1	NP_731790.1	7tmA_capaR	108..399	CDD:320262	103/305 (34%)
		TM helix 1	108..135	CDD:320262	12/26 (46%)
		TM helix 2	142..168	CDD:320262	16/25 (64%)
		TM helix 3	181..211	CDD:320262	12/29 (41%)
		TM helix 4	223..245	CDD:320262	6/21 (29%)
		TM helix 5	265..294	CDD:320262	12/28 (43%)
		TM helix 6	316..346	CDD:320262	12/29 (41%)
		TM helix 7	367..392	CDD:320262	9/24 (38%)