Protein Alignment NMUR2 and CapaR

DIOPT Version :10

• Sequence 1: NP_064552.3
• Gene: NMUR2 / 56923
• HGNCID: 16454
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_996140.1
• Gene: CapaR / 40393
• FlyBaseID: FBgn0037100
• Length: 477
• Species: Drosophila melanogaster
• Alignment Length: 365
• Identity: 121/365 - (33%)
• Similarity: 205/365 - (56%)
• Gaps: 48/365 - (13%)

Human    28 STEEYLAFLCGPRRSHFFLP------VSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFS 86
            |.:|::||:.||:.    ||      :::::..||:.||:||:|||:||::|.||.|.|||||||
  Fly    49 SPKEFVAFVLGPQT----LPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFS 109

Human    87 LAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHP 151
            |||||||.||.|:|.||:..|..||.|||...|..:..:.|...:.|:.:|...|:||::||.||
  Fly   110 LAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHP 174

Human   152 FRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFP-NGSLVPGSATCTVIKPMWIYNF 215
            .........:||:||:..:|..|.:.::|...:..|::..:| :.|.:..||.|: :.|..:...
  Fly   175 LHLYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCS-MSPKIVNEI 238

Human   216 -IIQVTSFLFYLLPMTVISVLYYLMA--LRLKKDKSLEADEGNANIQ----RPCRKSVNKMLFVL 273
             :.:|:..:|:::||.:|.:||..|.  :|.:.::.|...:|..|.:    :..:|:|.:||..:
  Fly   239 PVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAV 303

Human   274 VLVFAICWAPFHIDRLFFSFVEEWSESL---AAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQ 335
            |:.|.:||.|||:.||.|.:.:.....|   .|:|:    ::|..:|:|..||||:|:::|||::
  Fly   304 VITFFVCWFPFHLQRLIFLYAKNMDNYLDINEALFS----IAGFAYYVSCTVNPIVYSVMSRRYR 364

Human   336 AAFQNVI----------------------SSFHKQWHSQH 353
            .||:.::                      ||.:.:.||.|
  Fly   365 VAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVH 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tmA_NMU-R2	46..338	CDD:320479	108/308 (35%)
		TM helix 1	46..73	CDD:320479	13/32 (41%)
		TM helix 2	80..106	CDD:320479	20/25 (80%)
		TM helix 3	119..149	CDD:320479	8/29 (28%)
		TM helix 4	161..183	CDD:320479	7/21 (33%)
		TM helix 5	213..242	CDD:320479	8/31 (26%)
		TM helix 6	261..291	CDD:320479	13/29 (45%)
		TM helix 7	306..331	CDD:320479	8/24 (33%)
		NmU-R2_C_term	331..397	CDD:466027	10/45 (22%)
CapaR	NP_996140.1	7tmA_capaR	83..367	CDD:320262	103/288 (36%)
		TM helix 2	103..129	CDD:320262	20/25 (80%)
		TM helix 3	142..172	CDD:320262	8/29 (28%)
		TM helix 4	184..206	CDD:320262	7/21 (33%)
		TM helix 5	237..266	CDD:320262	8/28 (29%)
		TM helix 6	291..321	CDD:320262	13/29 (45%)
		TM helix 7	335..360	CDD:320262	10/28 (36%)