DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NMUR2 and CapaR

DIOPT Version :9

Sequence 1:	NP_064552.3	Gene:	NMUR2 / 56923	HGNCID:	16454	Length:	415	Species:	Homo sapiens
Sequence 2:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	121/365 - (33%)
Similarity:	205/365 - (56%)	Gaps:	48/365 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    28 STEEYLAFLCGPRRSHFFLP------VSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFS 86
            |.:|::||:.||:.    ||      :::::..||:.||:||:|||:||::|.||.|.|||||||
  Fly    49 SPKEFVAFVLGPQT----LPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFS 109

Human    87 LAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHP 151
            |||||||.||.|:|.||:..|..||.|||...|..:..:.|...:.|:.:|...|:||::||.||
  Fly   110 LAVSDLLYLLFGLPTEVFLYWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHP 174

Human   152 FRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFP-NGSLVPGSATCTVIKPMWIYNF 215
            .........:||:||:..:|..|.:.::|...:..|::..:| :.|.:..||.|: :.|..:...
  Fly   175 LHLYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCS-MSPKIVNEI 238

Human   216 -IIQVTSFLFYLLPMTVISVLYYLMA--LRLKKDKSLEADEGNANIQ----RPCRKSVNKMLFVL 273
             :.:|:..:|:::||.:|.:||..|.  :|.:.::.|...:|..|.:    :..:|:|.:||..:
  Fly   239 PVFEVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAV 303

Human   274 VLVFAICWAPFHIDRLFFSFVEEWSESL---AAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQ 335
            |:.|.:||.|||:.||.|.:.:.....|   .|:|:    ::|..:|:|..||||:|:::|||::
  Fly   304 VITFFVCWFPFHLQRLIFLYAKNMDNYLDINEALFS----IAGFAYYVSCTVNPIVYSVMSRRYR 364

Human   336 AAFQNVI----------------------SSFHKQWHSQH 353
            .||:.::                      ||.:.:.||.|
  Fly   365 VAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVH 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tm_1	62..327	CDD:278431	98/275 (36%)
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	104/293 (35%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	98/275 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145169
Domainoid	1	1.000	175	1.000	Domainoid score	I3659
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H49618
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3674
Isobase	1	0.950	-	0	Normalized mean entropy	S5676
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0001494
OrthoInspector	1	1.000	-	-		mtm8501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840