Protein Alignment NMUR2 and nmur-1

DIOPT Version :10

• Sequence 1: NP_064552.3
• Gene: NMUR2 / 56923
• HGNCID: 16454
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_509515.3
• Gene: nmur-1 / 183574
• WormBaseID: WBGene00016747
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 384
• Identity: 122/384 - (31%)
• Similarity: 186/384 - (48%)
• Gaps: 55/384 - (14%)

Human    23 QKHLNSTEEY---LAFLCGPRRSH-----------------------FFLPVSVVYVPIFVVGVI 61
            |..||:||:.   |||.|....||                       ....|:.:|:.||:||||
 Worm     3 QACLNTTEDQCDCLAFNCPIVYSHSESEKEACYMEHCFISKRALDDVTLYKVTALYIFIFLVGVI 67

Human    62 GNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALF 126
            ||...|||:.:|..|||..:.||.:||||||:.|.:|:|.||...|..||:.|....|..|..:.
 Worm    68 GNTTTCLVMKKHPMMKTHASMYLMNLAVSDLVTLCVGLPFEVMMNWNQYPWPFPDYICNLKALIA 132

Human   127 ETVCFASILSITTVSVERYVAILHP-FRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKF- 189
            ||....|||:|...::|||||:.|| |..|:|..:|....|:|..|.||:|.::|....|...:
 Worm   133 ETTSSVSILTILIFAIERYVAVCHPLFLMKVQPFKRNIGTIIGFTWIFSILCAMPFAIHHRADYI 197

Human   190 -HYFP---NGSLVPGSATCTVI-----KPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKK 245
             ..:|   |...|..|..|.:.     |....:..:...::..|:.||:..|.:||..:|.::..
 Worm   198 MKSWPGTDNRIPVKSSKMCMIAVMFEPKLASTFKILFHFSAIAFFALPLFTIVILYARIACKVSS 262

Human   246 DKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHV 310
            :::::  .|..:|....:..:|.:|..:|..|.||:.||.:.||.|.:.:. ...|..|...::.
 Worm   263 NRTIQ--PGELDITEELQMRINAILCAIVSAFFICYLPFQLQRLLFFYFDN-EVILTWVNQYMYF 324

Human   311 VSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI--------------SSFHKQWHSQHDP 355
            :||..|||::.:|||.|||.|.||:.||::::              |||.| :...|.|
 Worm   325 ISGFLFYLATIINPIAYNLASSRFRRAFKDILIDYCWRGGSERYPRSSFSK-YSLAHTP 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tmA_NMU-R2	46..338	CDD:320479	103/302 (34%)
		TM helix 1	46..73	CDD:320479	13/26 (50%)
		TM helix 2	80..106	CDD:320479	13/25 (52%)
		TM helix 3	119..149	CDD:320479	13/29 (45%)
		TM helix 4	161..183	CDD:320479	8/21 (38%)
		TM helix 5	213..242	CDD:320479	7/28 (25%)
		TM helix 6	261..291	CDD:320479	10/29 (34%)
		TM helix 7	306..331	CDD:320479	11/24 (46%)
		NmU-R2_C_term	331..397	CDD:466027	11/39 (28%)
nmur-1	NP_509515.3	7tmA_NTSR-like	52..352	CDD:320110	103/302 (34%)
		TM helix 1	52..79	CDD:320110	13/26 (50%)
		TM helix 2	86..112	CDD:320110	13/25 (52%)
		TM helix 3	125..155	CDD:320110	13/29 (45%)
		TM helix 4	168..190	CDD:320110	8/21 (38%)
		TM helix 5	230..259	CDD:320110	7/28 (25%)
		TM helix 6	276..306	CDD:320110	10/29 (34%)
		TM helix 7	320..345	CDD:320110	11/24 (46%)