Protein Alignment NMUR2 and nmur-2

DIOPT Version :10

• Sequence 1: NP_064552.3
• Gene: NMUR2 / 56923
• HGNCID: 16454
• Length: 415
• Species: Homo sapiens
• Sequence 2: NP_493666.2
• Gene: nmur-2 / 173398
• WormBaseID: WBGene00019616
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 353
• Identity: 116/353 - (32%)
• Similarity: 191/353 - (54%)
• Gaps: 38/353 - (10%)

Human    25 HLNSTEEYLAFLCGPR--RSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSL 87
            :::...||:....|.|  .:...:|..::|..||::|:.||:..|:||..:::|..|||||||||
 Worm     9 NVSEITEYVLSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSL 73

Human    88 AVSDLLVLLLGMPLEVYE-MWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHP 151
            ||||::.|:||:|:|.|: :..:||:.|....|..:..|.|...:|||:.|...|.||::||.||
 Worm    74 AVSDIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHP 138

Human   152 FRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGI---------KFHYFPN-----GSLVPGSA 202
            .|:|:.||..||..::.:.|..|.:.:||...|..|         |:..:.|     |..|..:.
 Worm   139 LRSKIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTE 203

Human   203 TCTVIKPMWIYNFIIQVTSF-LFYLLPMTVISVLYYLMALR-------LKKDKSLEADEGNANIQ 259
            .|.:.:.......:|.:.:| :|:::|...|.::|..:|::       ||.||.::.....:|
 Worm   204 FCAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRNKSN-- 266

Human   260 RPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES------LAAVFNLVHVVSGVFFYL 318
                ::|.|||..:|:.|.|||.||||.|| .|....|||:      :..:..:|..:||..:|.
 Worm   267 ----RTVLKMLLSVVITFFICWLPFHIQRL-LSVYTTWSETTTISPPVQFLSMIVFYISGFCYYS 326

Human   319 SSAVNPIIYNLLSRRFQAAFQNVISSFH 346
            :||.|||:||:||:::::||...|...|
 Worm   327 NSAANPILYNILSQKYRSAFCRTILGDH 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR2	NP_064552.3	7tmA_NMU-R2	46..338	CDD:320479	108/320 (34%)
		TM helix 1	46..73	CDD:320479	10/26 (38%)
		TM helix 2	80..106	CDD:320479	18/26 (69%)
		TM helix 3	119..149	CDD:320479	11/29 (38%)
		TM helix 4	161..183	CDD:320479	6/21 (29%)
		TM helix 5	213..242	CDD:320479	7/29 (24%)
		TM helix 6	261..291	CDD:320479	15/29 (52%)
		TM helix 7	306..331	CDD:320479	11/24 (46%)
		NmU-R2_C_term	331..397	CDD:466027	5/16 (31%)
nmur-2	NP_493666.2	7tmA_capaR	32..346	CDD:320262	108/320 (34%)
		TM helix 1	32..59	CDD:320262	10/26 (38%)
		TM helix 2	66..92	CDD:320262	18/25 (72%)
		TM helix 3	106..136	CDD:320262	11/29 (38%)
		TM helix 4	148..170	CDD:320262	6/21 (29%)
		TM helix 5	215..244	CDD:320262	7/28 (25%)
		TM helix 6	264..294	CDD:320262	16/36 (44%)
		TM helix 7	314..339	CDD:320262	11/24 (46%)