Protein Alignment UBQLN4 and DSK2

DIOPT Version :10

• Sequence 1: NP_064516.2
• Gene: UBQLN4 / 56893
• HGNCID: 1237
• Length: 601
• Species: Homo sapiens
• Sequence 2: NP_014003.1
• Gene: DSK2 / 855319
• SGDID: S000004889
• Length: 373
• Species: Saccharomyces cerevisiae
• Alignment Length: 606
• Identity: 140/606 - (23%)
• Similarity: 210/606 - (34%)
• Gaps: 253/606 - (41%)

Human    13 IRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLT 77
            :.:.:|:.:||.|:.:...::|.:|||.|::..........||::||||||..|:..:.|:||.:
Yeast     3 LNIHIKSGQDKWEVNVAPESTVLQFKEAINKANGIPVANQRLIYSGKILKDDQTVESYHIQDGHS 67

Human    78 VHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSD----AGSGSRRS 138
            |||| |:..|.|..:||.|::         .:.|.|:..|.|.|:.|...|:.    |...|.|.
Yeast    68 VHLV-KSQPKPQTASAAGANN---------ATATGAAAGTGATPNMSSGQSAGFNPLADLTSARY 122

Human   139 SGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENP 203
            :|....|.|....|.         ||.|...|                    :|.:.|.::||||
Yeast   123 AGYLNMPSADMFGPD---------GGALNNDS--------------------NNQDELLRMMENP 158

Human   204 LVQ----DMMSNPDLMRHMIMANPQMQQL------MERNPEISHMLNNPELMRQTMELARNPAMM 258
            :.|    :|:|||.::..||.:|||:|.:      |.::|....||.||:::||:|:.||   ||
Yeast   159 IFQSQMNEMLSNPQMLDFMIQSNPQLQAMGPQARQMLQSPMFRQMLTNPDMIRQSMQFAR---MM 220

Human   259 QEM--MRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPL 321
            ...  |.:...|.|...: |||                .|..|  |:|.      |:.|||:
Yeast   221 DPNAGMGSAGGAASAFPA-PGG----------------DAPEE--GSNT------NTTSSSN--- 257

Human   322 RTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQAL 386
                                   :|......:||:....|.:|||    |||
Yeast   258 -----------------------TGNNAGTNAGTNAGANTAANPF----ASL------------- 282

Human   387 LQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQM 451
                                                                             
Yeast   283 ----------------------------------------------------------------- 282

Human   452 QNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTS 516
                                              |.|:|..|.       :|| ||.|| ..|..
Yeast   283 ----------------------------------LNPALNPFA-------NAG-NAAST-GMPAF 304

Human   517 SPATPAT--SSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMGFINREANLQ 579
            .||..|:  ..|..||.|:                 ..:.||.|::.||.|||.|||.:.:.|:.
Yeast   305 DPALLASMFQPPVQASQAE-----------------DTRPPEERYEHQLRQLNDMGFFDFDRNVA 352

Human   580 ALIATGGDINAAIERLLGSQL 600
            ||..:||.:..|::.||...:
Yeast   353 ALRRSGGSVQGALDSLLNGDV 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN4	NP_064516.2	Ubl_PLICs	11..83	CDD:340506	25/69 (36%)
		rad23	13..>291	CDD:273167	85/293 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..155		19/71 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..366		11/64 (17%)
		STI1	393..>424	CDD:128966	0/30 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..533		15/44 (34%)
		UBA_PLICs	558..597	CDD:270582	16/38 (42%)
DSK2	NP_014003.1	Ubl_Dsk2p_like	3..74	CDD:340523	26/71 (37%)
		STI1	149..185	CDD:128966	15/35 (43%)
		UBA_Dsk2p_like	328..369	CDD:270509	17/40 (43%)