Protein Alignment UBQLN4 and Ubqn

DIOPT Version :10

• Sequence 1: NP_064516.2
• Gene: UBQLN4 / 56893
• HGNCID: 1237
• Length: 601
• Species: Homo sapiens
• Sequence 2: NP_608344.1
• Gene: Ubqn / 32977
• FlyBaseID: FBgn0031057
• Length: 547
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 289/619 - (46%)
• Similarity: 389/619 - (62%)
• Gaps: 92/619 - (14%)

Human     1 MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGD 65
            |||  |...|  |.|.|||||||:.:.:.:.:.:|:||..::::|:|:.:||||||||||:||.|
  Fly     1 MAE--GGSKR--INVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTD 61

Human    66 TLNQHGIKDGLTVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSD 130
            ||..|.|||.||||||||.|.:            :...||..|:....:|..
  Fly    62 TLQMHNIKDNLTVHLVIKAPTR------------NNEQPARQPADVRQTPFG------------- 101

Human   131 AGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEM 195
                                        |:.|||:.|:.:||.||..||:||.:||.:|::|.:|
  Fly   102 ----------------------------LNQFGGLAGMEALGAGSNTFMDLQARMQNELLNNGDM 138

Human   196 LSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQE 260
            |..:|:||:||.||:|||.||.:|.:||||..||:||||||||||||:|:||||||||||:|:||
  Fly   139 LRSLMDNPMVQQMMNNPDTMRQLITSNPQMHDLMQRNPEISHMLNNPDLLRQTMELARNPSMLQE 203

Human   261 MMRNQDRALSNLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSL--AGNSDSSSSQPLRT 323
            :||:.|||:|||||:||||:||:|:|.||||||.:||.|.||.|||:.|  .|.|.:.::....|
  Fly   204 LMRSHDRAMSNLESVPGGYSALQRIYRDIQEPMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGT 268

Human   324 ENREPLPNPWSPSPPTSQAPGSGGEGT-GGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALL 387
            |||.||||||.       ...||..|| ||||..  :||...|        .:.:.|:|.|::||
  Fly   269 ENRNPLPNPWG-------GANSGTNGTVGGSGAG--NPTGDLP--------PNNVLNTPAMRSLL 316

Human   388 QQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQ 452
            ||:::||.:|||:::|||.||||::::|:||.||:::.:.||.:.||.||||:|..:|.|:.|||
  Fly   317 QQMADNPAMMQNLLNAPYTRSMMESMSQDPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQ 381

Human   453 NPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLG------SFGISRTPAP---SAGSNAG 508
            |||.:::||||.||.|:||||||::.|::.|||||.:||      ..|....||.   |.|::..
  Fly   382 NPEVMNMLTNPDAMNAILQIQQGMEQLRSAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGA 446

Human   509 STPEAPTSSPATPATSSPT---GASSAQQQLMQQMIQLLAGSGNS--QVQTPEVRFQQQLEQLNS 568
            ||.....||.....|.:|.   |.....|.....|:::|.|..|:  ..|.||||:|.||||||:
  Fly   447 STNNVSPSSGLNAGTGTPNLAPGGGPNAQLFNDFMMRMLNGMSNNADNTQPPEVRYQSQLEQLNA 511

Human   569 MGFINREANLQALIATGGDINAAIERLLG-SQLS 601
            |||:||:|||||||||.||||||:||||. :|||
  Fly   512 MGFVNRDANLQALIATFGDINAAVERLLSLNQLS 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN4	NP_064516.2	Ubl_PLICs	11..83	CDD:340506	39/71 (55%)
		rad23	13..>291	CDD:273167	130/277 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..155		4/67 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..366		28/67 (42%)
		STI1	393..>424	CDD:128966	17/30 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..533		14/54 (26%)
		UBA_PLICs	558..597	CDD:270582	31/38 (82%)
Ubqn	NP_608344.1	Ubl_PLICs	7..79	CDD:340506	40/73 (55%)
		PABP-1234	<233..409	CDD:130689	90/192 (47%)
		UBA_PLICs	501..537	CDD:270582	28/35 (80%)