Protein Alignment UBQLN4 and dsk2

DIOPT Version :10

• Sequence 1: NP_064516.2
• Gene: UBQLN4 / 56893
• HGNCID: 1237
• Length: 601
• Species: Homo sapiens
• Sequence 2: NP_594159.1
• Gene: dsk2 / 2542667
• PomBaseID: SPAC26A3.16
• Length: 354
• Species: Schizosaccharomyces pombe
• Alignment Length: 619
• Identity: 125/619 - (20%)
• Similarity: 192/619 - (31%)
• Gaps: 306/619 - (49%)

Human    13 IRVTVKTPKDKEEIVICD-RASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGL 76
            |.:|:|...|::..|..| .:||...||.|:.....::::..||:||::|||.::|..:.|:||.
pombe     4 ISLTIKAANDQKYAVTVDSESSVLALKEAIAPVADIEKERQRLIYAGRVLKDEESLKTYKIQDGH 68

Human    77 TVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGG 141
            ::||| ||  ..|:||||               .|..|..|...|:     :..||.|:
pombe    69 SIHLV-KT--LGQNPAAA---------------ATNVSDRTQQVPT-----NIQAGQGA------ 104

Human   142 GPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQ 206
                                                                             
pombe   105 ----------------------------------------------------------------- 104

Human   207 DMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSN 271
                                             |||                          |:|
pombe   105 ---------------------------------NNP--------------------------LAN 110

Human   272 LESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPS 336
            |.|         ..|.....||.||:  .||                           |||.:|.
pombe   111 LTS---------ARYAGFNIPMPSAS--MFG---------------------------PNPENPV 137

Human   337 PPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVI 401
            ||:::                   .::|            |.::|.:|:.:.::..|||::..:|
pombe   138 PPSTE-------------------ELAN------------MLSNPMVQSSINEMFSNPQMLDMII 171

Human   402 -SAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILTNPRA 465
             |:|::|                  |.|                |...|.||:||....:|:|..
pombe   172 NSSPHLR------------------NAP----------------PYVRQMMQSPEFRRAMTDPDT 202

Human   466 MQALLQIQQGLQTLQTEAPGLVP------SLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATS 524
            |:.:.|:.|     |..|.|:.|      .||..|:........|...|          |..||:
pombe   203 MRQMAQLHQ-----QMGAAGIDPMSLMGGGLGGAGLGGLGGAGLGGFGG----------ANNATA 252

Human   525 SPTGASSAQQ----QLMQQMIQLLAGSG-----------------------NSQVQTPEVRFQQQ 562
            ...||:...|    ..:|.::..|.|:|                       ....:.||.|:.:|
pombe   253 GIAGAAPVDQTAAANTIQNLLNNLGGAGFGAGLGDAGLGAGLGGAASPPAPAQDTRPPEERYAEQ 317

Human   563 LEQLNSMGFINREANLQALIATGGDINAAIERLL 596
            |.|||.|||::.|.|:|||..:||::..|||.||
pombe   318 LSQLNEMGFVDFERNVQALRRSGGNVQGAIESLL 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN4	NP_064516.2	Ubl_PLICs	11..83	CDD:340506	25/70 (36%)
		rad23	13..>291	CDD:273167	47/278 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..155		12/67 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..366		9/64 (14%)
		STI1	393..>424	CDD:128966	7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..533		10/42 (24%)
		UBA_PLICs	558..597	CDD:270582	21/39 (54%)
dsk2	NP_594159.1	rad23	4..>169	CDD:273167	66/386 (17%)
		Ubl_Dsk2p_like	4..74	CDD:340523	25/70 (36%)
		UBA_Dsk2p_like	310..351	CDD:270509	21/40 (53%)