Protein Alignment UBQLN4 and ubql-1

DIOPT Version :10

• Sequence 1: NP_064516.2
• Gene: UBQLN4 / 56893
• HGNCID: 1237
• Length: 601
• Species: Homo sapiens
• Sequence 2: NP_740883.1
• Gene: ubql-1 / 172434
• WormBaseID: WBGene00008852
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 613
• Identity: 212/613 - (34%)
• Similarity: 304/613 - (49%)
• Gaps: 146/613 - (23%)

Human    13 IRVTVKTPKDKEEIVICDRASVKEFKEEISRRF-KAQQDQLVLIFAGKILKDGDTLNQHGIKDGL 76
            |:|.||:|.:|.::.|...|||.|.|:::.... .|.::|:.:|:.||||||.:||.||.|.||.
 Worm     8 IKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGH 72

Human    77 TVHLVIKTPQKAQDPAAATASSPSTPDPASAPSTTPASPATP-AQPSTSGSASSDAGSGSRRSSG 140
            ||||||:. |....||.|.|    ||..:||||:.|    || :||:.:.:..:..|
 Worm    73 TVHLVIRN-QARPTPAPAAA----TPTASSAPSSNP----TPSSQPNPTNNPFAAMG-------- 120

Human   141 GGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFMELQQQMQRQLMSNPEMLSQIMENPLV 205
                   |.|||:                                  .:::||:.:..:|:||:.
 Worm   121 -------GMGSPA----------------------------------DILNNPDAMRSVMDNPIT 144

Human   206 QDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALS 270
            |.::.||:.||.:|.:|||.|.|:|||||:.|:||:|.:||||||:.|||.|.||||||.|:|:.
 Worm   145 QQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIR 209

Human   271 NLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQP----LRTENREPLPN 331
            ||:.||||..||.|:|.|:|||:.::|......|||:||.|:   .||:|    ...||.|.|||
 Worm   210 NLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGD---QSSEPRVDRAGQENNEALPN 271

Human   332 PWSPSPPTSQAPGSGGEGTGGSGTSQVHPTVSNPFGINAASLGSGMFNSPEMQALLQQISENPQL 396
            ||:                  |..:|.....||    |.::..:.:.:||.:.:|::|:..||.:
 Worm   272 PWA------------------SNANQATNNQSN----NRSADFNSLLDSPGISSLMEQMMSNPSM 314

Human   397 MQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQMQNPESLSILT 461
            ..::.|...:.|:.|.::.||.....::..:|....|||:.|.:|...|..|..|.:|..:..:.
 Worm   315 QASMFSPEVINSIRQNMSNNPGLIDSIVGQIPSARDNPQISEGIRRSFPQMLNMMSDPSVMEAMR 379

Human   462 NPRAMQALLQIQQGLQTLQTEAPGLVPSL-------GSFGISRTPAPSAGSNA------------ 507
            |||..:|..|||:|..||:.|||.|:...       |:|| |...|.|||:|:
 Worm   380 NPRVSEAFRQIQEGFSTLRREAPQLLNLFQAGAMGGGAFG-SDANASSAGANSANGLADLFNSMN 443

Human   508 --GSTPEAPTSSPATPATSSPTGASSAQQQLMQQMIQLLAGSGNSQVQTPEVRFQQQLEQLNSMG 570
              |..|    ||.|.|.                               .||..:..|||||.|||
 Worm   444 MGGGRP----SSTAAPV-------------------------------NPEQTYASQLEQLQSMG 473

Human   571 FINREANLQALIATGGDINAAIERLLGS 598
            |.:|..|:.||.||.||:|||:||||.|
 Worm   474 FSDRARNVAALTATFGDLNAAVERLLNS 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UBQLN4	NP_064516.2	Ubl_PLICs	11..83	CDD:340506	33/70 (47%)
		rad23	13..>291	CDD:273167	109/279 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..155		20/68 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..366		21/68 (31%)
		STI1	393..>424	CDD:128966	7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..533		15/63 (24%)
		UBA_PLICs	558..597	CDD:270582	23/38 (61%)
ubql-1	NP_740883.1	Ubl_Dsk2p_like	8..80	CDD:340523	34/71 (48%)
		rad23	18..>372	CDD:273167	150/436 (34%)
		UBA_PLICs	461..500	CDD:270582	23/38 (61%)