DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSMB1 and Prosbeta6

DIOPT Version :9

Sequence 1:	NP_002784.1	Gene:	PSMB1 / 5689	HGNCID:	9537	Length:	241	Species:	Homo sapiens
Sequence 2:	NP_524115.1	Gene:	Prosbeta6 / 39855	FlyBaseID:	FBgn0002284	Length:	235	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	116/232 - (50%)
Similarity:	172/232 - (74%)	Gaps:	5/232 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    15 LGME---PHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTD 76
            ||.|   .::..|.....||||..|||:|:||||:|||::|:|||||.|::||:|...|.:||:.
  Fly     4 LGFEQFPDYQVPGMKHPDFSPYESNGGSIVAIAGDDFAVIAADTRLSSGYNIHSRTQSKLFKLSP 68

Human    77 KTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGL 141
            :||:|.:|...|.|:||..|:.|::.|:|::.:.|||.|:|.|||..:|:||||||||.||:.|:
  Fly    69 QTVLGSAGCWADTLSLTGSIKVRMQSYEHTHLRTMTTEAVAQMLSIAMYNRRFFPYYVSNILAGI 133

Human   142 DEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNM--QNVEHVPLSLDRAMRLVK 204
            |.||||.|||:||:|..::.:::|||:|..:|||:||||:|.|||  ::.:.:.|:.:||:.:..
  Fly   134 DNEGKGVVYSYDPIGHCEKATYRAGGTAGTLLQPVLDNQIGHKNMNLEDADKIKLTKERAVSVAS 198

Human   205 DVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD 241
            |.||||||||:||||::.|.|:||:||...|::||:|
  Fly   199 DTFISAAERDIYTGDSVLINIITKDGIEVRTLTLRQD 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSMB1	NP_002784.1	proteasome_beta_type_1	30..241	CDD:239726	111/212 (52%)
Prosbeta6	NP_524115.1	proteasome_beta_type_1	22..235	CDD:239726	111/212 (52%)
Prosbeta6	NP_524115.1	PRE1	24..225	CDD:223711	104/200 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160454
Domainoid	1	1.000	217	1.000	Domainoid score	I2688
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2087
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3324
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54193
OrthoDB	1	1.010	-	-		D1092660at2759
OrthoFinder	1	1.000	-	-		FOG0004805
OrthoInspector	1	1.000	-	-		oto91695
orthoMCL	1	0.900	-	-		OOG6_101631
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1009
SonicParanoid	1	1.000	-	-		X3385
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800