DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSMB1 and Prosbeta2

DIOPT Version :9

Sequence 1:	NP_002784.1	Gene:	PSMB1 / 5689	HGNCID:	9537	Length:	241	Species:	Homo sapiens
Sequence 2:	NP_524076.2	Gene:	Prosbeta2 / 39628	FlyBaseID:	FBgn0023174	Length:	272	Species:	Drosophila melanogaster

Alignment Length:	200	Identity:	49/200 - (24%)
Similarity:	94/200 - (47%)	Gaps:	21/200 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    37 GGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGC-SGFHGDCLTLTKIIEARL 100
            |.||:.|..:|..|:.:|||.:||..:..::..|.:.|. |.:..| :|...|....|.:|.::|
  Fly    39 GTTIVGIIYKDGVILGADTRATEGPIVSDKNCAKIHYLA-KNIYCCGAGTAADTEMTTDLISSQL 102

Human   101 KMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVY----NIIGGLDEEGKGAVYSFDPVGSYQRD 161
            ::::...::.:...|...||..:|     |.|..:    .::||:|:.|. .:||..|.||..:.
  Fly   103 ELHRLQTDREVRVVAANTMLKQML-----FRYQGHISAALVLGGVDKTGP-HIYSIHPHGSSDKL 161

Human   162 SFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIV 226
            .:...||.|.....:.:::  :|       ..||.:...:||:|...|....|:.:|..:.:|::
  Fly   162 PYATMGSGSLAAMTVFESR--WK-------PDLSEEEGKKLVRDAIASGVFNDLGSGSNIDLCVI 217

Human   227 TKEGI 231
            .|..:
  Fly   218 RKGSV 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSMB1	NP_002784.1	proteasome_beta_type_1	30..241	CDD:239726	49/199 (25%)
Prosbeta2	NP_524076.2	PRE1	42..232	CDD:223711	47/196 (24%)
		proteasome_beta_type_7	42..228	CDD:239732	47/196 (24%)
		Pr_beta_C	232..264	CDD:289249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810