DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PSMA5 and Prosalpha5

DIOPT Version :9

Sequence 1:	NP_002781.2	Gene:	PSMA5 / 5686	HGNCID:	9534	Length:	241	Species:	Homo sapiens
Sequence 2:	NP_477202.2	Gene:	Prosalpha5 / 36951	FlyBaseID:	FBgn0016697	Length:	244	Species:	Drosophila melanogaster

Alignment Length:	243	Identity:	172/243 - (70%)
Similarity:	204/243 - (83%)	Gaps:	2/243 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65
            ||||||||||||||||||||||||||||||||||||||||.|.|||.||||||||||||.||::|
  Fly     1 MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGICTPEGVVLAVEKRITSPLMVPSTVE 65

Human    66 KIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEE-DAD 129
            ||||:|.|||||.|||:|||:|||::||||.|||||.|||.|::||..||||.||:|||:. |:|
  Fly    66 KIVEVDKHIGCATSGLMADARTLIERARVECQNHWFVYNERMSIESCAQAVSTLAIQFGDSGDSD 130

Human   130 -PGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHKSMTLKE 193
             ..|||||||||:||.|::...|||:|||||||||:..|:||||.|||||.:||:::...:||.|
  Fly   131 GAAAMSRPFGVAILFAGIEAGQPQLWHMDPSGTFVRHGAKAIGSGSEGAQQNLQDLFRPDLTLDE 195

Human   194 AIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241
            ||..||..||||||||||:||:|:.|:...:.|:||||||:|:.||:|
  Fly   196 AIDISLNTLKQVMEEKLNSTNVEVMTMTKEREFYMFTKEEVEQHIKNI 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSMA5	NP_002781.2	proteasome_alpha_type_5	8..220	CDD:239722	153/213 (72%)
Prosalpha5	NP_477202.2	PRK03996	8..243	CDD:235192	164/234 (70%)
Prosalpha5	NP_477202.2	proteasome_alpha_type_5	8..222	CDD:239722	153/213 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143507
Domainoid	1	1.000	255	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2084
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2405
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54013
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0004131
OrthoInspector	1	1.000	-	-		oto88905
orthoMCL	1	0.900	-	-		OOG6_101621
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1007
SonicParanoid	1	1.000	-	-		X2875
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800