Protein Alignment gucy2cb and Gyc76C

DIOPT Version :10

• Sequence 1: XP_696628.5
• Gene: gucy2cb / 568219
• ZFINID: ZDB-GENE-130531-31
• Length: 1071
• Species: Danio rerio
• Sequence 2: NP_001163473.1
• Gene: Gyc76C / 8674026
• FlyBaseID: FBgn0266136
• Length: 1525
• Species: Drosophila melanogaster
• Alignment Length: 1030
• Identity: 291/1030 - (28%)
• Similarity: 466/1030 - (45%)
• Gaps: 220/1030 - (21%)

Zfish   196 DC----FWYINALEVSNGGFSPSLQEIEVIRNKEDLTKAMAKHNRESNLFILCGTPDDIMDLKNG 256
            ||    :||                  ::::|..:.|:          :::..|..:.::|..:.
  Fly   206 DCCRSGYWY------------------QLVQNTMNRTR----------IYVFLGAANSLVDFMSS 242

Zfish   257 TTDYD----SEIAFLLIDLYNDIYYKGQSNTFMRNV-----------------------LVLTMP 294
            .....    .|...:.:|:.  :|.:.::..::|.|                       :|.:.|
  Fly   243 METAGLFARGEYMVIFVDMM--VYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTP 305

Zfish   295 NTRKYT-----------------------IDTSGNNTMNDYIAAYHDAVLLFGQVMRNIQKSGSL 336
            .|:.|.                       ::::.:..::.|.|..:|:|.|:...:..:.:..:.
  Fly   306 PTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETR 370

Zfish   337 DIQD--MESVSMN-------YFRNVSFTGIAG-EYQLDQHGDRDLMFSLI------YTNNNN--- 382
            .:.|  :..|:.|       ..:|.::..|.| :.::||:||.:..||::      :.|:||
  Fly   371 VLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPC 435

Zfish   383 QYNI--LYQFNTSNNKTGLKDSSPSFIWQS--RLPNDSPSKGLS-----------VIEIIVIVLC 432
            .|::  :..|:........|..:.|..|.|  ..|.|.|..|.:           ...:..:||.
  Fly   436 NYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLG 500

Zfish   433 TVIGIMGTLAFIFYWQNRYYHHMQKRWS---HISSQL--ITPLELNEW---------NMISLKIE 483
            .::...|.:....|          ::|.   .|...|  |.|.|:..:         :.:||...
  Fly   501 VLLFCSGVITMSIY----------RKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSA 555

Zfish   484 ED--STENSTYILRRARYDKKIVILKEFRLTDGSFTEKQRI------ELNTLLKIDYCNLTKFYG 540
            :.  |...:.::....|....:|.:||.:     |..|:.|      |:..|.::.:.|:..|.|
  Fly   556 QSYGSRWTNQFVTSTGRLRGAVVRIKELK-----FPRKRDISREIMKEMRLLRELRHDNINSFIG 615

Zfish   541 TVKFDNEYFGVFEYGERGSLRYVLDDKISYPEETFMDWQFKISVMYDIAKGMSYLHTSNIAVHGR 605
            ..........|.:|..:|||..::::     |:..:|..|..|:::|:.|||.|:|.|.:..||.
  Fly   616 ASVEPTRILLVTDYCAKGSLYDIIEN-----EDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGN 675

Zfish   606 LKSTNCVVDNRMVVKIADFGFNTIVSPSED------------LWTAPEHLRK--PGISQKGDVYS 656
            |||:||||.:|.::::.|||.:.:...:|:            ||.|||.||.  .| |||||||:
  Fly   676 LKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHG-SQKGDVYA 739

Zfish   657 FAIISQEIMMRK-----CTFYTNTCSDRAEKL-ARVQYPSTTSFFRPDLNFESTSESE---EEVC 712
            ||||..||..||     ..|......|..:|| .:.:.|     |||::  ||..|:|   :.|.
  Fly   740 FAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDP-----FRPEV--ESIIEAESCPDYVL 797

Zfish   713 MLIRNCWDEDPDRRPDFKKIEIALWKIVSRDNQEHESYMENLIRRLQMYSRNLERLVEERTALYK 777
            ..||:||.|||:.||:|..|...|.|:   ...:.::.|:.::..::.|:.|||.:|.|||.|..
  Fly   798 ACIRDCWAEDPEERPEFSVIRNRLKKM---RGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLC 859

Zfish   778 AERDRADCLNFMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVVDMLNDI 842
            .|:.:.:.|...:||..|...|.....|||..:|.||||||||||||.:...|||::||:.|||:
  Fly   860 EEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDL 924

Zfish   843 YKNFDSILDNHDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSHLPGIPV 907
            |..||.|:..:|||||||||||||||||||.:||:|||.:|..|||::|..:...:::|.|...:
  Fly   925 YTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETL 989

Zfish   908 WIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTDCKFEYE 972
            .:|||:|:||..|||||:.|||||||||||||||||||.|..|:||:|......|.:....:..|
  Fly   990 KLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITE 1054

Zfish   973 ERGETFLKGKGKEMTYWLTGVTGEN---------YNLPTP--PTAENFQNLQQDLSEMIKTCLQK 1026
            :||...:||||..:|:|||| ..||         .::|.|  ........|..|..:.....:..
  Fly  1055 KRGLVNMKGKGDVVTWWLTG-ANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHF 1118

Zfish  1027 RPSGLWRRKTL--------------SARHRKLMVGVEMETTDQPEYLHLATGDFL 1067
            ..:|..|:.|:              |.|....||.......::|....|..|.|:
  Fly  1119 CGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFV 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gucy2cb	XP_696628.5	None
Gyc76C	NP_001163473.1	PBP1_SAP_GC-like	26..445	CDD:380593	38/268 (14%)
		PK_GC-A_B	543..827	CDD:270944	94/304 (31%)
		HNOBA	<833..881	CDD:462234	15/47 (32%)
		CYCc	860..1052	CDD:214485	101/191 (53%)