DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PSKH1 and pskh1

DIOPT Version :9

Sequence 1:	NP_006733.1	Gene:	PSKH1 / 5681	HGNCID:	9529	Length:	424	Species:	Homo sapiens
Sequence 2:	NP_001018546.1	Gene:	pskh1 / 554840	ZFINID:	ZDB-GENE-050119-1	Length:	422	Species:	Danio rerio

Alignment Length:	428	Identity:	345/428 - (80%)
Similarity:	378/428 - (88%)	Gaps:	10/428 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPA----ASQYAHP 61
            |||.|||||||||.||||||||||||.   ::||||:|| :.|. |..|.|.|:    :...|..
Zfish     1 MGCRTSKVLPEPPGDVQLDLVKKVEPH---QTDVYKNFI-KYDG-GGEKTGSPSPQGQSQAVAKV 60

Human    62 CPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAI 126
            ...||.|.....|::..|: :||||||||||||||||||||||||||||||||||||:|||||||
Zfish    61 SQSPPPANDQPEPADSHRK-KVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRSTRQPYAI 124

Human   127 KMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFT 191
            |||||:||||||||||||.|||||||.|||||:|||||.||||||||||||||||||||.:||||
Zfish   125 KMIETRYREGREVCESELCVLRRVRHTNIIQLMEVFETAERVYMVMELATGGELFDRIITRGSFT 189

Human   192 ERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKT 256
            |||||||||||||||:|||.|||||||||||||||||||.||||:||||||||.|||||:|||||
Zfish   190 ERDATRVLQMVLDGVKYLHTLGITHRDLKPENLLYYHPGADSKIMITDFGLASTRKKGDECLMKT 254

Human   257 TCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPW 321
            |||||||||||:||||||||:|||||||||:|||||||||||||||.|||||||:||||:|||||
Zfish   255 TCGTPEYIAPEILVRKPYTNAVDMWALGVISYILLSGTMPFEDDNRMRLYRQILKGKYSFSGEPW 319

Human   322 PSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQST 386
            |||||||||||||:|||||..|::|.|||:|||:||||||||||||||||||||||||||||.||
Zfish   320 PSVSNLAKDFIDRVLTVDPNERLSAGQALKHPWIVSMAASSSMKNLHRSISQNLLKRASSRCHST 384

Human   387 KSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG 424
            ||:||.||||||:|:|:||:||:||||||.|||||.||
Zfish   385 KSSQSARSSRSTKSSKARRLREKELRELNRRYQQQCNG 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PSKH1	NP_006733.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..80		5/23 (22%)
		STKc_PSKH1	96..355	CDD:270989	231/258 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..407		22/28 (79%)
pskh1	NP_001018546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..80		13/47 (28%)
		STKc_PSKH1	94..353	CDD:270989	231/258 (90%)
		S_TKc	96..353	CDD:214567	229/256 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..422		35/45 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342542
Domainoid	1	1.000	478	1.000	Domainoid score	I3095
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48461
Inparanoid	1	1.050	675	1.000	Inparanoid score	I4530
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D226497at7742
OrthoFinder	1	1.000	-	-		FOG0000163
OrthoInspector	1	1.000	-	-		oto47062
orthoMCL	1	0.900	-	-		OOG6_109509
Panther	1	1.100	-	-	LDO	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2971
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300